TY - JOUR
T1 - The Functions of Microparticles in Pre-Eclampsia
AU - van der Post, Joris A. M.
AU - Lok, Christianne A. R.
AU - Boer, Kees
AU - Sturk, Auguste
AU - Sargent, Ian L.
AU - Nieuwland, Rienk
PY - 2011
Y1 - 2011
N2 - Pre-eclampsia (P-EC), a heterogenic multisystem disorder characterized by hypertension and proteinuria, usually develops in the second half of pregnancy. The incidence is 2 to 5%, and P-EC is therefore a major cause of maternal and perinatal morbidity and mortality. Although the exact etiology is unknown, placental factors released into the maternal circulation lead to systemic maternal inflammation and endothelial dysfunction. Growing evidence indicates that placenta-derived microparticles, best known as syncytiotrophoblast microparticles (STBM), are important among these factors. This review provides an overview of the presence and function(s) of STBM and other cell-derived microparticles and exosomes
AB - Pre-eclampsia (P-EC), a heterogenic multisystem disorder characterized by hypertension and proteinuria, usually develops in the second half of pregnancy. The incidence is 2 to 5%, and P-EC is therefore a major cause of maternal and perinatal morbidity and mortality. Although the exact etiology is unknown, placental factors released into the maternal circulation lead to systemic maternal inflammation and endothelial dysfunction. Growing evidence indicates that placenta-derived microparticles, best known as syncytiotrophoblast microparticles (STBM), are important among these factors. This review provides an overview of the presence and function(s) of STBM and other cell-derived microparticles and exosomes
U2 - https://doi.org/10.1055/s-0030-1270342
DO - https://doi.org/10.1055/s-0030-1270342
M3 - Article
C2 - 21370216
SN - 0094-6176
VL - 37
SP - 146
EP - 152
JO - Seminars in Thrombosis and Hemostasis
JF - Seminars in Thrombosis and Hemostasis
IS - 2
ER -