The future of sudden cardiac death research

Ahmad S. Amin; Arthur A.M. Wilde

doi:https://doi.org/10.1016/j.ppedcard.2017.02.008

The future of sudden cardiac death research

Ahmad S. Amin, Arthur A.M. Wilde

Research output: Contribution to journal › Review article › Academic › peer-review

8 Citations (Scopus)

Abstract

Sudden unexplained death (SUD) in the young is a rare but tragic event. As genetic cardiac causes underlie the majority of SUD cases, surviving family members with the same genetic substrate as their deceased relative may be at increased risk. Presently, the diagnostic strategy to young SUD victims and their families is yet not standardized, the underlying aetiology in an important fraction of cases is still unravelled, and risk prediction in the genetically affected relatives is difficult due the variable expressivity of disease-causing mutations. In this review, we describe an ideal approach to SUD that is currently feasible but unfortunately not routinely followed in the clinical practice. We also discuss recent advancements in genetic technology and novel insights in the pathomechanism of genetic diseases that provide new opportunities for the future of sudden cardiac death research and management.

Original language	English
Pages (from-to)	49-54
Number of pages	6
Journal	Progress in Pediatric Cardiology
Volume	45
DOIs	https://doi.org/10.1016/j.ppedcard.2017.02.008
Publication status	Published - Jun 2017

Keywords

Autopsy
Cardiomyopathy
Out-of-hospital cardiac arrest
Sudden arrhythmia death syndrome
Sudden cardiac death
Sudden unexplained death
Young

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https://doi.org/10.1016/j.ppedcard.2017.02.008

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title = "The future of sudden cardiac death research",

abstract = "Sudden unexplained death (SUD) in the young is a rare but tragic event. As genetic cardiac causes underlie the majority of SUD cases, surviving family members with the same genetic substrate as their deceased relative may be at increased risk. Presently, the diagnostic strategy to young SUD victims and their families is yet not standardized, the underlying aetiology in an important fraction of cases is still unravelled, and risk prediction in the genetically affected relatives is difficult due the variable expressivity of disease-causing mutations. In this review, we describe an ideal approach to SUD that is currently feasible but unfortunately not routinely followed in the clinical practice. We also discuss recent advancements in genetic technology and novel insights in the pathomechanism of genetic diseases that provide new opportunities for the future of sudden cardiac death research and management.",

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T1 - The future of sudden cardiac death research

AU - Amin, Ahmad S.

AU - Wilde, Arthur A.M.

PY - 2017/6

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N2 - Sudden unexplained death (SUD) in the young is a rare but tragic event. As genetic cardiac causes underlie the majority of SUD cases, surviving family members with the same genetic substrate as their deceased relative may be at increased risk. Presently, the diagnostic strategy to young SUD victims and their families is yet not standardized, the underlying aetiology in an important fraction of cases is still unravelled, and risk prediction in the genetically affected relatives is difficult due the variable expressivity of disease-causing mutations. In this review, we describe an ideal approach to SUD that is currently feasible but unfortunately not routinely followed in the clinical practice. We also discuss recent advancements in genetic technology and novel insights in the pathomechanism of genetic diseases that provide new opportunities for the future of sudden cardiac death research and management.

AB - Sudden unexplained death (SUD) in the young is a rare but tragic event. As genetic cardiac causes underlie the majority of SUD cases, surviving family members with the same genetic substrate as their deceased relative may be at increased risk. Presently, the diagnostic strategy to young SUD victims and their families is yet not standardized, the underlying aetiology in an important fraction of cases is still unravelled, and risk prediction in the genetically affected relatives is difficult due the variable expressivity of disease-causing mutations. In this review, we describe an ideal approach to SUD that is currently feasible but unfortunately not routinely followed in the clinical practice. We also discuss recent advancements in genetic technology and novel insights in the pathomechanism of genetic diseases that provide new opportunities for the future of sudden cardiac death research and management.

KW - Autopsy

KW - Cardiomyopathy

KW - Out-of-hospital cardiac arrest

KW - Sudden arrhythmia death syndrome

KW - Sudden cardiac death

KW - Sudden unexplained death

KW - Young

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DO - https://doi.org/10.1016/j.ppedcard.2017.02.008

M3 - Review article

SN - 1058-9813

VL - 45

SP - 49

EP - 54

JO - Progress in Pediatric Cardiology

JF - Progress in Pediatric Cardiology

ER -

The future of sudden cardiac death research

Abstract

Keywords

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