The genetic background modifies the spontaneous and X-ray-induced tumor spectrum in the Apc1638N mouse model

C. Willemien Van Der Houven Van Oordt, Ron Smits, Theo G. Schouten, Jeanine J. Houwing-Duistermaat, Sophia L.H. Williamson, Arne Luz, P. Meera Khan, Alex J. Van Der Eb, Marco L. Breuer, Riccardo Fodde

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The effect of the genetic background on the tumor spectrum of Apc1638N, a mouse model for attenuated familial adenomatous polyposis (FAP), has been investigated in X-irradiated and untreated F1 hybrids between C57BL/6JIco- Apc1638N (B6) and A/JCrIBR (A/J), BALB/cByJIco (C) or C3H/HeOuJIco (C3). Similar to the Apc(Min) model, the Apc1638N intestinal tumor multiplicity seems to be modulated by Mom1. Moreover, several additional (X-ray- responsive) modifier loci appear also to affect the Apc1638N intestinal tumor number. The genetic background did not significantly influence the number of spontaneous desmoids and cutaneous cysts in Apc1638N. In general, X- irradiation increased the desmoid multiplicity in Apc1638N females but had no effect in males. The opposite was noted for the cyst multiplicity after X- rays. Surprisingly, X-irradiated CB6F1-Apc1638N females were highly susceptible to the development of ovarian tumors, which displayed clear loss of the wild-type Apc allele.

Original languageEnglish
Pages (from-to)191-198
Number of pages8
JournalGenes Chromosomes and Cancer
Issue number3
Publication statusPublished - Mar 1999
Externally publishedYes

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