TY - JOUR
T1 - The genetic background modifies the spontaneous and X-ray-induced tumor spectrum in the Apc1638N mouse model
AU - Willemien Van Der Houven Van Oordt, C.
AU - Smits, Ron
AU - Schouten, Theo G.
AU - Houwing-Duistermaat, Jeanine J.
AU - Williamson, Sophia L.H.
AU - Luz, Arne
AU - Meera Khan, P.
AU - Van Der Eb, Alex J.
AU - Breuer, Marco L.
AU - Fodde, Riccardo
N1 - Copyright: Copyright 2007 Elsevier B.V., All rights reserved.
PY - 1999/3
Y1 - 1999/3
N2 - The effect of the genetic background on the tumor spectrum of Apc1638N, a mouse model for attenuated familial adenomatous polyposis (FAP), has been investigated in X-irradiated and untreated F1 hybrids between C57BL/6JIco- Apc1638N (B6) and A/JCrIBR (A/J), BALB/cByJIco (C) or C3H/HeOuJIco (C3). Similar to the Apc(Min) model, the Apc1638N intestinal tumor multiplicity seems to be modulated by Mom1. Moreover, several additional (X-ray- responsive) modifier loci appear also to affect the Apc1638N intestinal tumor number. The genetic background did not significantly influence the number of spontaneous desmoids and cutaneous cysts in Apc1638N. In general, X- irradiation increased the desmoid multiplicity in Apc1638N females but had no effect in males. The opposite was noted for the cyst multiplicity after X- rays. Surprisingly, X-irradiated CB6F1-Apc1638N females were highly susceptible to the development of ovarian tumors, which displayed clear loss of the wild-type Apc allele.
AB - The effect of the genetic background on the tumor spectrum of Apc1638N, a mouse model for attenuated familial adenomatous polyposis (FAP), has been investigated in X-irradiated and untreated F1 hybrids between C57BL/6JIco- Apc1638N (B6) and A/JCrIBR (A/J), BALB/cByJIco (C) or C3H/HeOuJIco (C3). Similar to the Apc(Min) model, the Apc1638N intestinal tumor multiplicity seems to be modulated by Mom1. Moreover, several additional (X-ray- responsive) modifier loci appear also to affect the Apc1638N intestinal tumor number. The genetic background did not significantly influence the number of spontaneous desmoids and cutaneous cysts in Apc1638N. In general, X- irradiation increased the desmoid multiplicity in Apc1638N females but had no effect in males. The opposite was noted for the cyst multiplicity after X- rays. Surprisingly, X-irradiated CB6F1-Apc1638N females were highly susceptible to the development of ovarian tumors, which displayed clear loss of the wild-type Apc allele.
UR - http://www.scopus.com/inward/record.url?scp=0345003787&partnerID=8YFLogxK
U2 - https://doi.org/10.1002/(SICI)1098-2264(199903)24:3<191::AID-GCC3>3.0.CO;2-L
DO - https://doi.org/10.1002/(SICI)1098-2264(199903)24:3<191::AID-GCC3>3.0.CO;2-L
M3 - Article
C2 - 10451698
SN - 1045-2257
VL - 24
SP - 191
EP - 198
JO - Genes Chromosomes and Cancer
JF - Genes Chromosomes and Cancer
IS - 3
ER -