The genetic etiology of cannabis use initiation: a meta-analysis of genome-wide association studies, and a SNP-based heritability estimation.

K.J.H. Verweij; A.A.E. Vinkhuyzen; B. Benyamin; M.T. Lynskey; L. Quaye; A. Agrawal; S.D. Gordon; G.W. Montgomery; P.A.F. Madden; A.C. Heath; T.D. Spector; N.G. Martin; S.E. Medland

doi:https://doi.org/10.1111/j.1369-1600.2012.00478.x

The genetic etiology of cannabis use initiation: a meta-analysis of genome-wide association studies, and a SNP-based heritability estimation.

K.J.H. Verweij, A.A.E. Vinkhuyzen, B. Benyamin, M.T. Lynskey, L. Quaye, A. Agrawal, S.D. Gordon, G.W. Montgomery, P.A.F. Madden, A.C. Heath, T.D. Spector, N.G. Martin, S.E. Medland

Amsterdam UMC

Research output: Contribution to journal › Article › Academic › peer-review

44 Citations (Scopus)

Abstract

While initiation of cannabis use is around 40% heritable, not much is known about the underlying genetic aetiology. Here, we meta-analysed two genome-wide association studies of initiation of cannabis use with > 10 000 individuals. None of the genetic variants reached genome-wide significance. We also performed a gene-based association test, which also revealed no significant effects of individual genes. Finally, we estimated that only approximately 6% of the variation in cannabis initiation is due to common genetic variants. Future genetic studies using larger sample sizes and different methodologies (including sequencing) might provide more insight in the complex genetic aetiology of cannabis use. © 2012 The Authors, Addiction Biology © 2012 Society for the Study of Addiction.

Original language	English
Pages (from-to)	846-850
Journal	Addiction Biology
Volume	18
Issue number	5
DOIs	https://doi.org/10.1111/j.1369-1600.2012.00478.x
Publication status	Published - 2013

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Verweij, K. J. H., Vinkhuyzen, A. A. E., Benyamin, B., Lynskey, M. T., Quaye, L., Agrawal, A., Gordon, S. D., Montgomery, G. W., Madden, P. A. F., Heath, A. C., Spector, T. D., Martin, N. G., & Medland, S. E. (2013). The genetic etiology of cannabis use initiation: a meta-analysis of genome-wide association studies, and a SNP-based heritability estimation. Addiction Biology, 18(5), 846-850. https://doi.org/10.1111/j.1369-1600.2012.00478.x

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abstract = "While initiation of cannabis use is around 40% heritable, not much is known about the underlying genetic aetiology. Here, we meta-analysed two genome-wide association studies of initiation of cannabis use with > 10 000 individuals. None of the genetic variants reached genome-wide significance. We also performed a gene-based association test, which also revealed no significant effects of individual genes. Finally, we estimated that only approximately 6% of the variation in cannabis initiation is due to common genetic variants. Future genetic studies using larger sample sizes and different methodologies (including sequencing) might provide more insight in the complex genetic aetiology of cannabis use. {\textcopyright} 2012 The Authors, Addiction Biology {\textcopyright} 2012 Society for the Study of Addiction.",

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Verweij, KJH, Vinkhuyzen, AAE, Benyamin, B, Lynskey, MT, Quaye, L, Agrawal, A, Gordon, SD, Montgomery, GW, Madden, PAF, Heath, AC, Spector, TD, Martin, NG & Medland, SE 2013, 'The genetic etiology of cannabis use initiation: a meta-analysis of genome-wide association studies, and a SNP-based heritability estimation.', Addiction Biology, vol. 18, no. 5, pp. 846-850. https://doi.org/10.1111/j.1369-1600.2012.00478.x

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AU - Verweij, K.J.H.

AU - Vinkhuyzen, A.A.E.

AU - Benyamin, B.

AU - Lynskey, M.T.

AU - Quaye, L.

AU - Agrawal, A.

AU - Gordon, S.D.

AU - Montgomery, G.W.

AU - Madden, P.A.F.

AU - Heath, A.C.

AU - Spector, T.D.

AU - Martin, N.G.

AU - Medland, S.E.

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AB - While initiation of cannabis use is around 40% heritable, not much is known about the underlying genetic aetiology. Here, we meta-analysed two genome-wide association studies of initiation of cannabis use with > 10 000 individuals. None of the genetic variants reached genome-wide significance. We also performed a gene-based association test, which also revealed no significant effects of individual genes. Finally, we estimated that only approximately 6% of the variation in cannabis initiation is due to common genetic variants. Future genetic studies using larger sample sizes and different methodologies (including sequencing) might provide more insight in the complex genetic aetiology of cannabis use. © 2012 The Authors, Addiction Biology © 2012 Society for the Study of Addiction.

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The genetic etiology of cannabis use initiation: a meta-analysis of genome-wide association studies, and a SNP-based heritability estimation.

Abstract

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