The histone H1(0)/H5 variant and terminal differentiation of cells during development of Xenopus laevis

A. F. Moorman; P. A. de Boer; R. Charles; W. H. Lamers

doi:https://doi.org/10.1111/j.1432-0436.1987.tb00156.x

The histone H1(0)/H5 variant and terminal differentiation of cells during development of Xenopus laevis

A. F. Moorman, P. A. de Boer, R. Charles, W. H. Lamers

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Abstract

The maintenance of the differentiated condition is supposed to be associated with the presence of a histone of the H1(0)/H5 subclass. If the H1(0)/H5 variant has an important role in differentiation distinct from that of H1, it should display differential expression in time and position during development. Here we report that this prediction is verified during Xenopus laevis development, in which tadpoles exhibit a very characteristic, developmentally regulated pattern of histone H1(0)/H5 expression that is different for the derivatives of each embryonic germ layer. However, the pattern of appearance of this variant during development does not reflect a simple correlation between its presence and the state of differentiation. Therefore, these results are pertinent to current ideas on differentiation and the involvement of lysine-rich histones in the repression of eukaryotic genes

Original language	English
Pages (from-to)	100-107
Journal	Differentiation; research in biological diversity
Volume	35
Issue number	2
DOIs	https://doi.org/10.1111/j.1432-0436.1987.tb00156.x
Publication status	Published - 1987

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https://doi.org/10.1111/j.1432-0436.1987.tb00156.x

Cite this

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title = "The histone H1(0)/H5 variant and terminal differentiation of cells during development of Xenopus laevis",

abstract = "The maintenance of the differentiated condition is supposed to be associated with the presence of a histone of the H1(0)/H5 subclass. If the H1(0)/H5 variant has an important role in differentiation distinct from that of H1, it should display differential expression in time and position during development. Here we report that this prediction is verified during Xenopus laevis development, in which tadpoles exhibit a very characteristic, developmentally regulated pattern of histone H1(0)/H5 expression that is different for the derivatives of each embryonic germ layer. However, the pattern of appearance of this variant during development does not reflect a simple correlation between its presence and the state of differentiation. Therefore, these results are pertinent to current ideas on differentiation and the involvement of lysine-rich histones in the repression of eukaryotic genes",

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