The immunoregulatory role of CD1d-restricted natural killer T cells in disease

Hans J J van der Vliet; Johan W Molling; B Mary E von Blomberg; Nobusuke Nishi; Wendy Kölgen; Alfons J M van den Eertwegh; Herbert M Pinedo; Giuseppe Giaccone; Rik J Scheper

doi:https://doi.org/10.1016/j.clim.2004.03.003

The immunoregulatory role of CD1d-restricted natural killer T cells in disease

Hans J J van der Vliet, Johan W Molling, B Mary E von Blomberg, Nobusuke Nishi, Wendy Kölgen, Alfons J M van den Eertwegh, Herbert M Pinedo, Giuseppe Giaccone, Rik J Scheper

Research output: Contribution to journal › Review article › Academic › peer-review

110 Citations (Scopus)

Abstract

Natural killer T (NKT) cells constitute a T cell subpopulation that shares several characteristics with NK cells. NKT cells are characterized by a narrow T cell antigen receptor (TCR) repertoire, recognize glycolipid antigen in the context of the monomorphic CD1d antigen-presenting molecule, and have the unique capacity to rapidly produce large amounts of both T helper (Th) 1 and Th2 cytokines. Important roles of NKT cells have now been demonstrated in the regulation of autoimmune, allergic, antimicrobial, and antitumor immune responses. Here, we review the immunoregulatory role of NKT cells in disease and discuss NKT cell based immunotherapeutic strategies.

Original language	English
Pages (from-to)	8-23
Number of pages	16
Journal	Clinical Immunology
Volume	112
Issue number	1
DOIs	https://doi.org/10.1016/j.clim.2004.03.003
Publication status	Published - Jul 2004

Keywords

Adjuvants, Immunologic
Animals
Antigens, CD1/immunology
Antigens, CD1d
Autoimmune Diseases/immunology
Communicable Diseases/immunology
Galactosylceramides/immunology
Graft Survival/immunology
Humans
Hypersensitivity/immunology
Immunotherapy/methods
Killer Cells, Natural/cytology
Mice
Neoplasms/immunology
T-Lymphocytes/cytology

Access to Document

https://doi.org/10.1016/j.clim.2004.03.003

Cite this

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title = "The immunoregulatory role of CD1d-restricted natural killer T cells in disease",

abstract = "Natural killer T (NKT) cells constitute a T cell subpopulation that shares several characteristics with NK cells. NKT cells are characterized by a narrow T cell antigen receptor (TCR) repertoire, recognize glycolipid antigen in the context of the monomorphic CD1d antigen-presenting molecule, and have the unique capacity to rapidly produce large amounts of both T helper (Th) 1 and Th2 cytokines. Important roles of NKT cells have now been demonstrated in the regulation of autoimmune, allergic, antimicrobial, and antitumor immune responses. Here, we review the immunoregulatory role of NKT cells in disease and discuss NKT cell based immunotherapeutic strategies.",

keywords = "Adjuvants, Immunologic, Animals, Antigens, CD1/immunology, Antigens, CD1d, Autoimmune Diseases/immunology, Communicable Diseases/immunology, Galactosylceramides/immunology, Graft Survival/immunology, Humans, Hypersensitivity/immunology, Immunotherapy/methods, Killer Cells, Natural/cytology, Mice, Neoplasms/immunology, T-Lymphocytes/cytology",

author = "{van der Vliet}, {Hans J J} and Molling, {Johan W} and {von Blomberg}, {B Mary E} and Nobusuke Nishi and Wendy K{\"o}lgen and {van den Eertwegh}, {Alfons J M} and Pinedo, {Herbert M} and Giuseppe Giaccone and Scheper, {Rik J}",

year = "2004",

month = jul,

doi = "https://doi.org/10.1016/j.clim.2004.03.003",

language = "English",

volume = "112",

pages = "8--23",

journal = "Clinical Immunology",

issn = "1521-6616",

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T1 - The immunoregulatory role of CD1d-restricted natural killer T cells in disease

AU - van der Vliet, Hans J J

AU - Molling, Johan W

AU - von Blomberg, B Mary E

AU - Nishi, Nobusuke

AU - Kölgen, Wendy

AU - van den Eertwegh, Alfons J M

AU - Pinedo, Herbert M

AU - Giaccone, Giuseppe

AU - Scheper, Rik J

PY - 2004/7

Y1 - 2004/7

N2 - Natural killer T (NKT) cells constitute a T cell subpopulation that shares several characteristics with NK cells. NKT cells are characterized by a narrow T cell antigen receptor (TCR) repertoire, recognize glycolipid antigen in the context of the monomorphic CD1d antigen-presenting molecule, and have the unique capacity to rapidly produce large amounts of both T helper (Th) 1 and Th2 cytokines. Important roles of NKT cells have now been demonstrated in the regulation of autoimmune, allergic, antimicrobial, and antitumor immune responses. Here, we review the immunoregulatory role of NKT cells in disease and discuss NKT cell based immunotherapeutic strategies.

AB - Natural killer T (NKT) cells constitute a T cell subpopulation that shares several characteristics with NK cells. NKT cells are characterized by a narrow T cell antigen receptor (TCR) repertoire, recognize glycolipid antigen in the context of the monomorphic CD1d antigen-presenting molecule, and have the unique capacity to rapidly produce large amounts of both T helper (Th) 1 and Th2 cytokines. Important roles of NKT cells have now been demonstrated in the regulation of autoimmune, allergic, antimicrobial, and antitumor immune responses. Here, we review the immunoregulatory role of NKT cells in disease and discuss NKT cell based immunotherapeutic strategies.

KW - Adjuvants, Immunologic

KW - Animals

KW - Antigens, CD1/immunology

KW - Antigens, CD1d

KW - Autoimmune Diseases/immunology

KW - Communicable Diseases/immunology

KW - Galactosylceramides/immunology

KW - Graft Survival/immunology

KW - Humans

KW - Hypersensitivity/immunology

KW - Immunotherapy/methods

KW - Killer Cells, Natural/cytology

KW - Mice

KW - Neoplasms/immunology

KW - T-Lymphocytes/cytology

U2 - https://doi.org/10.1016/j.clim.2004.03.003

DO - https://doi.org/10.1016/j.clim.2004.03.003

M3 - Review article

C2 - 15207777

SN - 1521-6616

VL - 112

SP - 8

EP - 23

JO - Clinical Immunology

JF - Clinical Immunology

IS - 1

ER -