The IMP dehydrogenase inhibitor mycophenolic acid antagonizes the CTP synthetase inhibitor 3-deazauridine in MOLT-3 human leukemia cells: a central role for phosphoribosyl pyrophosphate

A. A. van Berg; P. A. Mooyer; H. van Lenthe; E. H. Stet; R. A. de Abreu; A. B. van Kuilenburg; A. H. van Gennip

doi:https://doi.org/10.1016/0006-2952(95)00228-R

The IMP dehydrogenase inhibitor mycophenolic acid antagonizes the CTP synthetase inhibitor 3-deazauridine in MOLT-3 human leukemia cells: a central role for phosphoribosyl pyrophosphate

A. A. van Berg, P. A. Mooyer, H. van Lenthe, E. H. Stet, R. A. de Abreu, A. B. van Kuilenburg, A. H. van Gennip

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Research output: Contribution to journal › Comment/Letter to the editor › Academic

2 Citations (Scopus)

Abstract

Mycophenolic acid, an inhibitor of the enzyme IMP dehydrogenase, antagonizes the CTP synthetase inhibitor 3-deazauridine in its anti-proliferative effects on MOLT-3 human T leukemia cells. No depletion of CTP occurred, and decreased amounts of 3-deazuridine-triphosphate were measured in cells incubated with mycophenolic acid and 3-deazuridine. Most probably, these phenomena are related to the increased amounts of PRPP observed, which can result in an increased pyrimidine biosynthesis de novo and, as a consequence, a decreased metabolism of 3-deazauridine via the salvage pathway

Original language	English
Pages (from-to)	1095-1098
Journal	Biochemical Pharmacology
Volume	50
Issue number	7
DOIs	https://doi.org/10.1016/0006-2952(95)00228-R
Publication status	Published - 1995

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https://doi.org/10.1016/0006-2952(95)00228-R

Cite this

van Berg, A. A., Mooyer, P. A., van Lenthe, H., Stet, E. H., de Abreu, R. A., van Kuilenburg, A. B., & van Gennip, A. H. (1995). The IMP dehydrogenase inhibitor mycophenolic acid antagonizes the CTP synthetase inhibitor 3-deazauridine in MOLT-3 human leukemia cells: a central role for phosphoribosyl pyrophosphate. Biochemical Pharmacology, 50(7), 1095-1098. https://doi.org/10.1016/0006-2952(95)00228-R

@article{adad1742e53e432d8b21b31eccee55be,

title = "The IMP dehydrogenase inhibitor mycophenolic acid antagonizes the CTP synthetase inhibitor 3-deazauridine in MOLT-3 human leukemia cells: a central role for phosphoribosyl pyrophosphate",

abstract = "Mycophenolic acid, an inhibitor of the enzyme IMP dehydrogenase, antagonizes the CTP synthetase inhibitor 3-deazauridine in its anti-proliferative effects on MOLT-3 human T leukemia cells. No depletion of CTP occurred, and decreased amounts of 3-deazuridine-triphosphate were measured in cells incubated with mycophenolic acid and 3-deazuridine. Most probably, these phenomena are related to the increased amounts of PRPP observed, which can result in an increased pyrimidine biosynthesis de novo and, as a consequence, a decreased metabolism of 3-deazauridine via the salvage pathway",

author = "{van Berg}, {A. A.} and Mooyer, {P. A.} and {van Lenthe}, H. and Stet, {E. H.} and {de Abreu}, {R. A.} and {van Kuilenburg}, {A. B.} and {van Gennip}, {A. H.}",

year = "1995",

doi = "https://doi.org/10.1016/0006-2952(95)00228-R",

language = "English",

volume = "50",

pages = "1095--1098",

journal = "Biochemical Pharmacology",

issn = "0006-2952",

publisher = "Elsevier Inc.",

number = "7",

}

van Berg, AA, Mooyer, PA, van Lenthe, H, Stet, EH, de Abreu, RA, van Kuilenburg, AB & van Gennip, AH 1995, 'The IMP dehydrogenase inhibitor mycophenolic acid antagonizes the CTP synthetase inhibitor 3-deazauridine in MOLT-3 human leukemia cells: a central role for phosphoribosyl pyrophosphate', Biochemical Pharmacology, vol. 50, no. 7, pp. 1095-1098. https://doi.org/10.1016/0006-2952(95)00228-R

The IMP dehydrogenase inhibitor mycophenolic acid antagonizes the CTP synthetase inhibitor 3-deazauridine in MOLT-3 human leukemia cells: a central role for phosphoribosyl pyrophosphate. / van Berg, A. A.; Mooyer, P. A.; van Lenthe, H. et al.
In: Biochemical Pharmacology, Vol. 50, No. 7, 1995, p. 1095-1098.

Research output: Contribution to journal › Comment/Letter to the editor › Academic

TY - JOUR

T1 - The IMP dehydrogenase inhibitor mycophenolic acid antagonizes the CTP synthetase inhibitor 3-deazauridine in MOLT-3 human leukemia cells: a central role for phosphoribosyl pyrophosphate

AU - van Berg, A. A.

AU - Mooyer, P. A.

AU - van Lenthe, H.

AU - Stet, E. H.

AU - de Abreu, R. A.

AU - van Kuilenburg, A. B.

AU - van Gennip, A. H.

PY - 1995

Y1 - 1995

N2 - Mycophenolic acid, an inhibitor of the enzyme IMP dehydrogenase, antagonizes the CTP synthetase inhibitor 3-deazauridine in its anti-proliferative effects on MOLT-3 human T leukemia cells. No depletion of CTP occurred, and decreased amounts of 3-deazuridine-triphosphate were measured in cells incubated with mycophenolic acid and 3-deazuridine. Most probably, these phenomena are related to the increased amounts of PRPP observed, which can result in an increased pyrimidine biosynthesis de novo and, as a consequence, a decreased metabolism of 3-deazauridine via the salvage pathway

AB - Mycophenolic acid, an inhibitor of the enzyme IMP dehydrogenase, antagonizes the CTP synthetase inhibitor 3-deazauridine in its anti-proliferative effects on MOLT-3 human T leukemia cells. No depletion of CTP occurred, and decreased amounts of 3-deazuridine-triphosphate were measured in cells incubated with mycophenolic acid and 3-deazuridine. Most probably, these phenomena are related to the increased amounts of PRPP observed, which can result in an increased pyrimidine biosynthesis de novo and, as a consequence, a decreased metabolism of 3-deazauridine via the salvage pathway

U2 - https://doi.org/10.1016/0006-2952(95)00228-R

DO - https://doi.org/10.1016/0006-2952(95)00228-R

M3 - Comment/Letter to the editor

C2 - 7575666

SN - 0006-2952

VL - 50

SP - 1095

EP - 1098

JO - Biochemical Pharmacology

JF - Biochemical Pharmacology

IS - 7

ER -