TY - JOUR
T1 - The impact of diabetes on the pathogenesis of sepsis
AU - Koh, G. C. K. W.
AU - Peacock, S. J.
AU - van der Poll, T.
AU - Wiersinga, W. J.
PY - 2012
Y1 - 2012
N2 - Diabetes is associated with an increased susceptibility to infection and sepsis. Conflicting data exist on whether the mortality of patients with sepsis is influenced by the presence of diabetes, fuelling the ongoing debate on the benefit of tight glucose regulation in patients with sepsis. The main reason for which diabetes predisposes to infection appears to be abnormalities of the host response, particularly in neutrophil chemotaxis, adhesion and intracellular killing, defects that have been attributed to the effect of hyperglycaemia. There is also evidence for defects in humoral immunity, and this may play a larger role than previously recognised. We review the literature on the immune response in diabetes and its potential contribution to the pathogenesis of sepsis. In addition, the effect of diabetes treatment on the immune response is discussed, with specific reference to insulin, metformin, sulphonylureas and thiazolidinediones
AB - Diabetes is associated with an increased susceptibility to infection and sepsis. Conflicting data exist on whether the mortality of patients with sepsis is influenced by the presence of diabetes, fuelling the ongoing debate on the benefit of tight glucose regulation in patients with sepsis. The main reason for which diabetes predisposes to infection appears to be abnormalities of the host response, particularly in neutrophil chemotaxis, adhesion and intracellular killing, defects that have been attributed to the effect of hyperglycaemia. There is also evidence for defects in humoral immunity, and this may play a larger role than previously recognised. We review the literature on the immune response in diabetes and its potential contribution to the pathogenesis of sepsis. In addition, the effect of diabetes treatment on the immune response is discussed, with specific reference to insulin, metformin, sulphonylureas and thiazolidinediones
U2 - https://doi.org/10.1007/s10096-011-1337-4
DO - https://doi.org/10.1007/s10096-011-1337-4
M3 - Review article
C2 - 21805196
SN - 0934-9723
VL - 31
SP - 379
EP - 388
JO - European journal of clinical microbiology & infectious diseases
JF - European journal of clinical microbiology & infectious diseases
IS - 4
ER -