The impact of exclusive enteral nutrition (EEN) on the gut microbiome in Crohn’s disease: A review

Amber MacLellan, Jessica Connors, Shannan Grant, Leah Cahill, Morgan G. I. Langille, Johan van Limbergen

Research output: Contribution to journalReview articleAcademicpeer-review

79 Citations (Scopus)

Abstract

Crohn’s disease (CD), a form of inflammatory bowel disease (IBD), is thought to arise from a complex interaction of genetics, the gut microbiome, and environmental factors, such as diet. There is clear evidence that dietary intervention is successful in the treatment of CD—exclusive enteral nutrition (EEN) is able to induce remission in up to 80% of CD patients. While the mechanism of action of EEN is not clear, EEN is known to cause profound changes in the gut microbiome. Understanding how EEN modifies the gut microbiome to induce remission could provide insight into CD etiopathogenesis and aid the development of microbiome-targeted interventions to guide ongoing dietary therapy to sustain remission. This review includes current literature on changes in composition and function of the gut microbiome associated with EEN treatment in CD patients.
Original languageEnglish
Article number447
JournalNUTRIENTS
Volume9
Issue number5
DOIs
Publication statusPublished - 1 May 2017
Externally publishedYes

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