TY - JOUR
T1 - The Impact of Filter Settings on Morphology of Unipolar Fibrillation Potentials
AU - Starreveld, Roeliene
AU - Knops, Paul
AU - Roos-Serote, Maarten
AU - Kik, Charles
AU - Bogers, Ad J.J.C.
AU - Brundel, Bianca J.J.M.
AU - de Groot, Natasja M.S.
PY - 2020/12
Y1 - 2020/12
N2 - Using unipolar atrial electrogram morphology as guidance for ablative therapy is regaining interest. Although standardly used in clinical practice during ablative therapy, the impact of filter settings on morphology of unipolar AF potentials is unknown. Thirty different filters were applied to 2,557,045 high-resolution epicardial AF potentials recorded from ten patients. Deflections with slope ≤ − 0.05 mV/ms and amplitude ≥ 0.3 mV were marked. High-pass filtering decreased the number of detected potentials, deflection amplitude, and percentage of fractionated potentials (≥ 2 deflections) as well as fractionation delay time (FDT) and increased percentage of single potentials. Low-pass filtering decreased the number of potentials, percentage of fractionated potentials, whereas deflection amplitude, percentage of single potentials, and FDT increased. Notch filtering (50 Hz) decreased the number of potentials and deflection amplitude, whereas the percentage of complex fractionated potentials (≥ 3 deflections) increased. Filtering significantly impacted morphology of unipolar fibrillation potentials, becoming a potential source of error in identification of ablative targets. [Figure not available: see fulltext.].
AB - Using unipolar atrial electrogram morphology as guidance for ablative therapy is regaining interest. Although standardly used in clinical practice during ablative therapy, the impact of filter settings on morphology of unipolar AF potentials is unknown. Thirty different filters were applied to 2,557,045 high-resolution epicardial AF potentials recorded from ten patients. Deflections with slope ≤ − 0.05 mV/ms and amplitude ≥ 0.3 mV were marked. High-pass filtering decreased the number of detected potentials, deflection amplitude, and percentage of fractionated potentials (≥ 2 deflections) as well as fractionation delay time (FDT) and increased percentage of single potentials. Low-pass filtering decreased the number of potentials, percentage of fractionated potentials, whereas deflection amplitude, percentage of single potentials, and FDT increased. Notch filtering (50 Hz) decreased the number of potentials and deflection amplitude, whereas the percentage of complex fractionated potentials (≥ 3 deflections) increased. Filtering significantly impacted morphology of unipolar fibrillation potentials, becoming a potential source of error in identification of ablative targets. [Figure not available: see fulltext.].
KW - Atrial fibrillation
KW - Cardiac electrophysiology
KW - Electrogram morphology
KW - Filter settings
KW - High-resolution epicardial mapping
UR - http://www.scopus.com/inward/record.url?scp=85084841195&partnerID=8YFLogxK
U2 - https://doi.org/10.1007/s12265-020-10011-w
DO - https://doi.org/10.1007/s12265-020-10011-w
M3 - Article
C2 - 32410210
SN - 1937-5387
VL - 13
SP - 953
EP - 964
JO - Journal of cardiovascular translational research
JF - Journal of cardiovascular translational research
IS - 6
ER -