The in vitro diagnosis of drug allergy: status and perspectives

D. G. Ebo; J. Leysen; C. Mayorga; A. Rozieres; E. F. Knol; I. Terreehorst

doi:https://doi.org/10.1111/j.1398-9995.2011.02661.x

The in vitro diagnosis of drug allergy: status and perspectives

D. G. Ebo, J. Leysen, C. Mayorga, A. Rozieres, E. F. Knol, I. Terreehorst

Research output: Contribution to journal › Review article › Academic › peer-review

94 Citations (Scopus)

Abstract

Adverse drug reactions (ADR) can result from immune-mediated (drug allergy) and nonimmune-mediated mechanisms. In both types of reaction, conclusive diagnosis and appropriate management remain major problems in daily clinical practice. This review summarizes the potentials and shortcomings of the currently available in vitro tests in the diagnosis of immediate (mostly IgE mediated) and nonimmediate (mostly T-cell mediated) drug allergy, particularly quantification of specific IgE, flow-assisted analysis of in vitro activated lymphocytes and basophils and the enzyme-linked immunosorbent spot

Original language	English
Pages (from-to)	1275-1286
Journal	Allergy
Volume	66
Issue number	10
DOIs	https://doi.org/10.1111/j.1398-9995.2011.02661.x
Publication status	Published - 2011

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https://doi.org/10.1111/j.1398-9995.2011.02661.x

Cite this

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AU - Knol, E. F.

AU - Terreehorst, I.

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AB - Adverse drug reactions (ADR) can result from immune-mediated (drug allergy) and nonimmune-mediated mechanisms. In both types of reaction, conclusive diagnosis and appropriate management remain major problems in daily clinical practice. This review summarizes the potentials and shortcomings of the currently available in vitro tests in the diagnosis of immediate (mostly IgE mediated) and nonimmediate (mostly T-cell mediated) drug allergy, particularly quantification of specific IgE, flow-assisted analysis of in vitro activated lymphocytes and basophils and the enzyme-linked immunosorbent spot

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DO - https://doi.org/10.1111/j.1398-9995.2011.02661.x

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