TY - JOUR
T1 - The influence of apical periodontitis on circulatory inflammatory mediators in peripheral blood
T2 - A prospective case–control study
AU - Georgiou, Athina Christina
AU - Twisk, Jos W. R.
AU - Crielaard, Wim
AU - Ouwerling, Peter
AU - Schoneveld, Arjan H.
AU - van der Waal, Suzette Veronica
N1 - Funding Information: This study was funded partially by the annual research prize of the European Society of Endodontology (ESE) and by the department of Preventive Dentistry of the Academic Centre for Dentistry Amsterdam (ACTA). Publisher Copyright: © 2022 The Authors. International Endodontic Journal published by John Wiley & Sons Ltd on behalf of British Endodontic Society.
PY - 2023/2
Y1 - 2023/2
N2 - Aim: To explore the influence of apical periodontitis (AP) on inflammatory markers in blood of otherwise healthy individuals and to depict the inflammatory profile of the healing after dental extraction. Methodology: This is a prospective case–control intervention study, during which, individuals with a diagnosis of AP of one affected tooth were included, along with a control group matched for age and gender. A broad panel of blood inflammatory mediators was examined longitudinally in all subjects during six visits. In the case of the AP subjects, the tooth with AP was extracted at the third visit. Results were analysed by linear regression analyses and linear mixed-model analyses. Results: A total of 53 subjects were included in the study, 27 with AP and 26 without. Fifteen females and 12 males were included in the AP group, and 14 females and 12 males in the control group. At baseline, granulocyte colony-stimulating factor (p <.001), interleukin (IL)-1β (p =.03) and IL-4 (p =.01) were significantly lower in AP subjects than in controls. Comparison of the differences between baseline and the last visit, i.e. 3 months after the tooth extraction, showed a significant reduction in IL-10 (p =.03) and IL-12p70 (p =.01). Conclusions: The immunologic profile of chronic AP in one tooth and its healing profile reveals a systemic low-grade inflammation through compensatory immunosuppression. A larger lesion or multiple lesions could disrupt the balance that the system is trying to maintain, resulting in loss of homeostasis.
AB - Aim: To explore the influence of apical periodontitis (AP) on inflammatory markers in blood of otherwise healthy individuals and to depict the inflammatory profile of the healing after dental extraction. Methodology: This is a prospective case–control intervention study, during which, individuals with a diagnosis of AP of one affected tooth were included, along with a control group matched for age and gender. A broad panel of blood inflammatory mediators was examined longitudinally in all subjects during six visits. In the case of the AP subjects, the tooth with AP was extracted at the third visit. Results were analysed by linear regression analyses and linear mixed-model analyses. Results: A total of 53 subjects were included in the study, 27 with AP and 26 without. Fifteen females and 12 males were included in the AP group, and 14 females and 12 males in the control group. At baseline, granulocyte colony-stimulating factor (p <.001), interleukin (IL)-1β (p =.03) and IL-4 (p =.01) were significantly lower in AP subjects than in controls. Comparison of the differences between baseline and the last visit, i.e. 3 months after the tooth extraction, showed a significant reduction in IL-10 (p =.03) and IL-12p70 (p =.01). Conclusions: The immunologic profile of chronic AP in one tooth and its healing profile reveals a systemic low-grade inflammation through compensatory immunosuppression. A larger lesion or multiple lesions could disrupt the balance that the system is trying to maintain, resulting in loss of homeostasis.
KW - apical periodontitis
KW - endodontics
KW - low-grade inflammation
KW - systemic health
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U2 - https://doi.org/10.1111/iej.13854
DO - https://doi.org/10.1111/iej.13854
M3 - Article
C2 - 36284462
SN - 0143-2885
VL - 56
SP - 130
EP - 145
JO - International endodontic journal
JF - International endodontic journal
IS - 2
ER -