TY - JOUR
T1 - The Influence of Mechanical Bowel Preparation on Volatile Organic Compounds for the Detection of Gastrointestinal Disease-A Systematic Review
AU - Krishnamoorthy, Ashwin
AU - Chandrapalan, Subashini
AU - Bosch, Sofie
AU - Bannaga, Ayman
AU - de Boer, Nanne K. H.
AU - de Meij, Tim G. J.
AU - Leja, Marcis
AU - Hanna, George B.
AU - de Vietro, Nicoletta
AU - Altomare, Donato
AU - Arasaradnam, Ramesh P.
N1 - Publisher Copyright: © 2023 by the authors.
PY - 2023/2/1
Y1 - 2023/2/1
N2 - (1) Background: Colorectal cancer is the second commonest cause of cancer deaths worldwide; recently, volatile organic compounds (VOCs) have been proposed as potential biomarkers of this disease. In this paper, we aim to identify and review the available literature on the influence of mechanical bowel preparation on VOC production and measurement. (2) Methods: A systematic search for studies was carried out for articles relevant to mechanical bowel preparation and its effects on volatile organic compounds. A total of 4 of 1349 papers initially derived from the search were selected. (3) Results: Two studies with a total of 134 patients found no difference in measured breath VOC profiles after bowel preparation; one other study found an increase in breath acetone in 61 patients after bowel preparation, but no other compounds were affected. Finally, the last study showed the alteration of urinary VOC profiles. (4) Conclusions: There is limited data on the effect of bowel preparation on VOC production in the body. As further studies of VOCs are conducted in patients with symptoms of gastrointestinal disease, the quantification of the effect of bowel preparation on their abundance is required.
AB - (1) Background: Colorectal cancer is the second commonest cause of cancer deaths worldwide; recently, volatile organic compounds (VOCs) have been proposed as potential biomarkers of this disease. In this paper, we aim to identify and review the available literature on the influence of mechanical bowel preparation on VOC production and measurement. (2) Methods: A systematic search for studies was carried out for articles relevant to mechanical bowel preparation and its effects on volatile organic compounds. A total of 4 of 1349 papers initially derived from the search were selected. (3) Results: Two studies with a total of 134 patients found no difference in measured breath VOC profiles after bowel preparation; one other study found an increase in breath acetone in 61 patients after bowel preparation, but no other compounds were affected. Finally, the last study showed the alteration of urinary VOC profiles. (4) Conclusions: There is limited data on the effect of bowel preparation on VOC production in the body. As further studies of VOCs are conducted in patients with symptoms of gastrointestinal disease, the quantification of the effect of bowel preparation on their abundance is required.
KW - colorectal cancer
KW - mechanical bowel preparation
KW - volatile organic compound
UR - http://www.scopus.com/inward/record.url?scp=85147893593&partnerID=8YFLogxK
U2 - https://doi.org/10.3390/s23031377
DO - https://doi.org/10.3390/s23031377
M3 - Review article
C2 - 36772415
SN - 1424-8220
VL - 23
JO - Sensors (Basel, Switzerland)
JF - Sensors (Basel, Switzerland)
IS - 3
M1 - 1377
ER -