The influence of premature ventricular contractions on left ventricular function in asymptomatic children without structural heart disease: an echocardiographic evaluation

Yiping Sun; Nico A. Blom; Yonghui Yu; Peiran Ma; Yi Wang; Xiuzhen Han; Cees A. Swenne; Ernst E. van der Wall

doi:https://doi.org/10.1023/A:1025418531853

The influence of premature ventricular contractions on left ventricular function in asymptomatic children without structural heart disease: an echocardiographic evaluation

Yiping Sun, Nico A. Blom, Yonghui Yu, Peiran Ma, Yi Wang, Xiuzhen Han, Cees A. Swenne, Ernst E. van der Wall

Paediatric Cardiology (AMC)

Research output: Contribution to journal › Article › Academic › peer-review

61 Citations (Scopus)

Abstract

BACKGROUND: Isolated monomorphic premature ventricular contractions (PVCs) are not uncommon in the pediatric population. The degree of cardiac dysfunction caused by PVCs in children without structural heart disease is unknown. PURPOSE: To investigate the influence of PVCs on echocardiographic left ventricular (LV) systolic function in children without structural heart disease. METHODS: Forty asymptomatic children with isolated monomorphic PVCs without structural heart disease were selected. The median age was 6 years, range of 3-12 years. The following subgroups were compared: frequent vs. infrequent PVCs (> or <or = 10/min); short vs. long coupling interval (RR'/RR ratio <or = or > 0.6); and short vs. long QT interval (QT <or = or > 400 ms). Using echocardiography the left ventricular ejection fraction (LVEF in percentage) and cardiac index (CI in L/min/m2) were measured for both normal sinus beats (SB-LVEF and CI), PVCs (PVC-LVEF and CI) and the average LVEF and CI were calculated. All values were expressed as means +/- SD. RESULTS: In all children LV dimensions and the SB-LVEF and CI were within normal limits. The PVC-LVEF (48 +/- 5) and PVC-CI (1.57 +/- 0.19) were significantly decreased and the average CI was 2.41 +/- 0.29. In 27 pts with > 10 PVCs/min the average LVEF and CI decreased to 53 +/- 5 and 2.08 +/- 0.24 respectively. In 16 pts with PVCs and a short coupling interval (RR'/RR <or = 0.6) the PVC-LVEF and PVC-CI was 43 +/- 0.03 and 1.50 +/- 0.14, which was significantly lower than in 24 pts with a long coupling interval (58 +/- 4, 1.88 +/- 0.11). In 11 pts with a prolonged QT interval (> 400 ms) the PVC-LVEF and PVC-CI was significantly lower than in the 29 children with a shorter QT interval, 41 +/- 5 vs. 55 +/- 4 and 1.46 +/- 0.13 vs. 1.86 +/- 0.15 respectively (all p <0.01). CONCLUSION: In asymptomatic children with isolated monomorphic PVCs the average ejection fraction and cardiac output is markedly reduced if PVCs are frequent (> 10/min), have a short coupling interval or a prolonged QT interval

Original language	English
Pages (from-to)	295-299
Journal	international journal of cardiovascular imaging
Volume	19
Issue number	4
DOIs	https://doi.org/10.1023/A:1025418531853
Publication status	Published - 2003

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https://doi.org/10.1023/A:1025418531853

Cite this

Sun, Y., Blom, N. A., Yu, Y., Ma, P., Wang, Y., Han, X., Swenne, C. A., & van der Wall, E. E. (2003). The influence of premature ventricular contractions on left ventricular function in asymptomatic children without structural heart disease: an echocardiographic evaluation. international journal of cardiovascular imaging, 19(4), 295-299. https://doi.org/10.1023/A:1025418531853

@article{977d3f540bd4479f8054eb0eb610f4c4,

title = "The influence of premature ventricular contractions on left ventricular function in asymptomatic children without structural heart disease: an echocardiographic evaluation",

abstract = "BACKGROUND: Isolated monomorphic premature ventricular contractions (PVCs) are not uncommon in the pediatric population. The degree of cardiac dysfunction caused by PVCs in children without structural heart disease is unknown. PURPOSE: To investigate the influence of PVCs on echocardiographic left ventricular (LV) systolic function in children without structural heart disease. METHODS: Forty asymptomatic children with isolated monomorphic PVCs without structural heart disease were selected. The median age was 6 years, range of 3-12 years. The following subgroups were compared: frequent vs. infrequent PVCs (> or 0.6); and short vs. long QT interval (QT 400 ms). Using echocardiography the left ventricular ejection fraction (LVEF in percentage) and cardiac index (CI in L/min/m2) were measured for both normal sinus beats (SB-LVEF and CI), PVCs (PVC-LVEF and CI) and the average LVEF and CI were calculated. All values were expressed as means +/- SD. RESULTS: In all children LV dimensions and the SB-LVEF and CI were within normal limits. The PVC-LVEF (48 +/- 5) and PVC-CI (1.57 +/- 0.19) were significantly decreased and the average CI was 2.41 +/- 0.29. In 27 pts with > 10 PVCs/min the average LVEF and CI decreased to 53 +/- 5 and 2.08 +/- 0.24 respectively. In 16 pts with PVCs and a short coupling interval (RR'/RR 400 ms) the PVC-LVEF and PVC-CI was significantly lower than in the 29 children with a shorter QT interval, 41 +/- 5 vs. 55 +/- 4 and 1.46 +/- 0.13 vs. 1.86 +/- 0.15 respectively (all p <0.01). CONCLUSION: In asymptomatic children with isolated monomorphic PVCs the average ejection fraction and cardiac output is markedly reduced if PVCs are frequent (> 10/min), have a short coupling interval or a prolonged QT interval",

author = "Yiping Sun and Blom, {Nico A.} and Yonghui Yu and Peiran Ma and Yi Wang and Xiuzhen Han and Swenne, {Cees A.} and {van der Wall}, {Ernst E.}",

year = "2003",

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pages = "295--299",

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Sun, Y, Blom, NA, Yu, Y, Ma, P, Wang, Y, Han, X, Swenne, CA & van der Wall, EE 2003, 'The influence of premature ventricular contractions on left ventricular function in asymptomatic children without structural heart disease: an echocardiographic evaluation', international journal of cardiovascular imaging, vol. 19, no. 4, pp. 295-299. https://doi.org/10.1023/A:1025418531853

The influence of premature ventricular contractions on left ventricular function in asymptomatic children without structural heart disease: an echocardiographic evaluation. / Sun, Yiping; Blom, Nico A.; Yu, Yonghui et al.
In: international journal of cardiovascular imaging, Vol. 19, No. 4, 2003, p. 295-299.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - The influence of premature ventricular contractions on left ventricular function in asymptomatic children without structural heart disease: an echocardiographic evaluation

AU - Sun, Yiping

AU - Blom, Nico A.

AU - Yu, Yonghui

AU - Ma, Peiran

AU - Wang, Yi

AU - Han, Xiuzhen

AU - Swenne, Cees A.

AU - van der Wall, Ernst E.

PY - 2003

Y1 - 2003

N2 - BACKGROUND: Isolated monomorphic premature ventricular contractions (PVCs) are not uncommon in the pediatric population. The degree of cardiac dysfunction caused by PVCs in children without structural heart disease is unknown. PURPOSE: To investigate the influence of PVCs on echocardiographic left ventricular (LV) systolic function in children without structural heart disease. METHODS: Forty asymptomatic children with isolated monomorphic PVCs without structural heart disease were selected. The median age was 6 years, range of 3-12 years. The following subgroups were compared: frequent vs. infrequent PVCs (> or 0.6); and short vs. long QT interval (QT 400 ms). Using echocardiography the left ventricular ejection fraction (LVEF in percentage) and cardiac index (CI in L/min/m2) were measured for both normal sinus beats (SB-LVEF and CI), PVCs (PVC-LVEF and CI) and the average LVEF and CI were calculated. All values were expressed as means +/- SD. RESULTS: In all children LV dimensions and the SB-LVEF and CI were within normal limits. The PVC-LVEF (48 +/- 5) and PVC-CI (1.57 +/- 0.19) were significantly decreased and the average CI was 2.41 +/- 0.29. In 27 pts with > 10 PVCs/min the average LVEF and CI decreased to 53 +/- 5 and 2.08 +/- 0.24 respectively. In 16 pts with PVCs and a short coupling interval (RR'/RR 400 ms) the PVC-LVEF and PVC-CI was significantly lower than in the 29 children with a shorter QT interval, 41 +/- 5 vs. 55 +/- 4 and 1.46 +/- 0.13 vs. 1.86 +/- 0.15 respectively (all p <0.01). CONCLUSION: In asymptomatic children with isolated monomorphic PVCs the average ejection fraction and cardiac output is markedly reduced if PVCs are frequent (> 10/min), have a short coupling interval or a prolonged QT interval

AB - BACKGROUND: Isolated monomorphic premature ventricular contractions (PVCs) are not uncommon in the pediatric population. The degree of cardiac dysfunction caused by PVCs in children without structural heart disease is unknown. PURPOSE: To investigate the influence of PVCs on echocardiographic left ventricular (LV) systolic function in children without structural heart disease. METHODS: Forty asymptomatic children with isolated monomorphic PVCs without structural heart disease were selected. The median age was 6 years, range of 3-12 years. The following subgroups were compared: frequent vs. infrequent PVCs (> or 0.6); and short vs. long QT interval (QT 400 ms). Using echocardiography the left ventricular ejection fraction (LVEF in percentage) and cardiac index (CI in L/min/m2) were measured for both normal sinus beats (SB-LVEF and CI), PVCs (PVC-LVEF and CI) and the average LVEF and CI were calculated. All values were expressed as means +/- SD. RESULTS: In all children LV dimensions and the SB-LVEF and CI were within normal limits. The PVC-LVEF (48 +/- 5) and PVC-CI (1.57 +/- 0.19) were significantly decreased and the average CI was 2.41 +/- 0.29. In 27 pts with > 10 PVCs/min the average LVEF and CI decreased to 53 +/- 5 and 2.08 +/- 0.24 respectively. In 16 pts with PVCs and a short coupling interval (RR'/RR 400 ms) the PVC-LVEF and PVC-CI was significantly lower than in the 29 children with a shorter QT interval, 41 +/- 5 vs. 55 +/- 4 and 1.46 +/- 0.13 vs. 1.86 +/- 0.15 respectively (all p <0.01). CONCLUSION: In asymptomatic children with isolated monomorphic PVCs the average ejection fraction and cardiac output is markedly reduced if PVCs are frequent (> 10/min), have a short coupling interval or a prolonged QT interval

U2 - https://doi.org/10.1023/A:1025418531853

DO - https://doi.org/10.1023/A:1025418531853

M3 - Article

C2 - 14598897

SN - 1569-5794

VL - 19

SP - 295

EP - 299

JO - international journal of cardiovascular imaging

JF - international journal of cardiovascular imaging

IS - 4

ER -