The influence of social, psychological, and cognitive factors on the clinical course in older patients with bipolar disorder

Melis Orhan, Janette Huijser, Nicole Korten, Nadine Paans, Eline Regeer, Caroline Sonnenberg, Patricia van Oppen, Max Stek, Ralph Kupka, Annemiek Dols

Research output: Contribution to journalArticleAcademicpeer-review

2 Citations (Scopus)


Objectives: Research on factors that contribute to recurrence in older adults with bipolar disorder (OABD) is sparse. Previous research showed that clinical factors (e.g., age of onset, lifetime psychotic features, and suicide risk) were not associated with the recurrence in OABD. In younger adults, worse social functioning, coping style, and worse cognitive functioning are found to be associated with an unfavorable course of bipolar disorder. Therefore, this study is focusing on social, psychological, and cognitive factors in OABD. More insight in these factors is essential in order to develop and further specify preventive and treatment interventions. Methods: Data were used from the Dutch Older Bipolars (DOBi) cohort study. We included 64 patients for 3-year follow-up measurements, who were divided in a recurrent group and a nonrecurrent group. Logistic regression analyses were conducted to assess associations between social, psychological, and cognitive factors, and nonrecurrence. Results: 39.1% reported at least one recurrence during the 3-year follow-up period. No significant associations were found between the social, psychological, and cognitive factors and having a recurrence during the follow-up period. Discussion: Participants in the recurrent group were younger, more often female and less likely to have children. Our results suggest that results from the adult bipolar disorder population cannot be extrapolated to OABD patients, underlining the need for longitudinal studies in OABD.

Original languageEnglish
Pages (from-to)342-348
Number of pages7
JournalInternational journal of geriatric psychiatry
Issue number2
Publication statusPublished - Feb 2021


  • bipolar disorder
  • cognitive
  • course
  • factors
  • older patients
  • psychological
  • social

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