TY - JOUR
T1 - The interface between medically assisted reproduction and genetics
T2 - Technical, social, ethical and legal issues
AU - Soini, Sirpa
AU - Ibarreta, Dolores
AU - Anastasiadou, Violetta
AU - Aymé, Ségolène
AU - Braga, Suzanne
AU - Cornel, Martina
AU - Coviello, Domenico A.
AU - Evers-Kiebooms, Gerry
AU - Geraedts, Joep
AU - Gianaroli, Luca
AU - Harper, Joyce
AU - Kosztolanyi, György
AU - Lundin, Kersti
AU - Rodrigues-Cerezo, Emilio
AU - Sermon, Karen
AU - Sequeiros, Jorge
AU - Tranebjaerg, Lisbeth
AU - Kääriäinen, Helena
PY - 2006/10/15
Y1 - 2006/10/15
N2 - The interface between assisted reproductive technologies (ART) and genetics comprises several sensitive and important issues that affect infertile couples, families with severe genetic diseases, potential children, professionals in ART and genetics, health care, researchers and the society in general. Genetic causes have a considerable involvement in infertility. Genetic conditions may also be transmitted to the offspring and hence create transgenerational infertility or other serious health problems. Several studies also suggest a slightly elevated risk of birth defects in children born following ART. PGD has become widely practiced throughout the world for various medical indications, but its limits are being debated. The attitudes towards ART and PGD vary substantially within Europe. The purpose of this article was to outline a framework for development of guidelines to be issued jointly by European Society of Human Genetics (ESHG) and European Society of Human Reproduction and Embryology (ESHRE) for the interface between genetics and ART. Technical, social, ethical and legal issues of ART and genetics will be reviewed.
AB - The interface between assisted reproductive technologies (ART) and genetics comprises several sensitive and important issues that affect infertile couples, families with severe genetic diseases, potential children, professionals in ART and genetics, health care, researchers and the society in general. Genetic causes have a considerable involvement in infertility. Genetic conditions may also be transmitted to the offspring and hence create transgenerational infertility or other serious health problems. Several studies also suggest a slightly elevated risk of birth defects in children born following ART. PGD has become widely practiced throughout the world for various medical indications, but its limits are being debated. The attitudes towards ART and PGD vary substantially within Europe. The purpose of this article was to outline a framework for development of guidelines to be issued jointly by European Society of Human Genetics (ESHG) and European Society of Human Reproduction and Embryology (ESHRE) for the interface between genetics and ART. Technical, social, ethical and legal issues of ART and genetics will be reviewed.
KW - Assisted reproductive technology
KW - Birth defects
KW - Counselling
KW - Genetic diseases
KW - Infertility
KW - PGD
UR - http://www.scopus.com/inward/record.url?scp=33749071016&partnerID=8YFLogxK
U2 - https://doi.org/10.1093/humrep/del390
DO - https://doi.org/10.1093/humrep/del390
M3 - Review article
SN - 1477-741X
VL - 1
SP - 2
EP - 51
JO - ESHRE Monographs
JF - ESHRE Monographs
ER -