TY - JOUR
T1 - The Light Green Cells of Lymnaea: a neuroendocrine model system for stimulus-induced expression of multiple peptide genes in a single cell type
T2 - A neuroendocrine model system for stimulus-induced expression of multiple peptide genes in a single cell type
AU - Geraerts, W. P.
AU - Smit, A. B.
AU - Li, K. W.
AU - Hordijk, P. L.
PY - 1992/5
Y1 - 1992/5
N2 - We review recent experiments showing that the cerebral neuroendocrine Light Green Cells (LGCs) of the freshwater snail, Lymnaea stagnalis, express a family of distinct though related molluscan insulin-related peptide (MIP) genes. The LGCs are involved in the regulation of a wide range of interrelated life processes associated with growth, (energy) metabolism and reproduction. We consider the mechanism of generation of diversity among MIPs, and present evidence that conditions with distinct effects on growth, metabolism and reproduction also can induce distinct patterns of expression of the MIP and schistosomin genes. The stimulus-dependent expression of multiple neuropeptide genes enormously increases the adaptive potential of a peptidergic neuron. We suggest that this contributes significantly to the information-handling capacity of the brain
AB - We review recent experiments showing that the cerebral neuroendocrine Light Green Cells (LGCs) of the freshwater snail, Lymnaea stagnalis, express a family of distinct though related molluscan insulin-related peptide (MIP) genes. The LGCs are involved in the regulation of a wide range of interrelated life processes associated with growth, (energy) metabolism and reproduction. We consider the mechanism of generation of diversity among MIPs, and present evidence that conditions with distinct effects on growth, metabolism and reproduction also can induce distinct patterns of expression of the MIP and schistosomin genes. The stimulus-dependent expression of multiple neuropeptide genes enormously increases the adaptive potential of a peptidergic neuron. We suggest that this contributes significantly to the information-handling capacity of the brain
KW - evolution
KW - generation of neuropeptide diversity
KW - information-handling capacity
KW - Molluscan insulin-related peptides
KW - neuropeptide gene family
KW - schistosomin
KW - stimulus-dependent expression
UR - http://www.scopus.com/inward/record.url?scp=0026659533&partnerID=8YFLogxK
U2 - https://doi.org/10.1007/BF01928165
DO - https://doi.org/10.1007/BF01928165
M3 - Article
C2 - 1601111
SN - 0014-4754
VL - 48
SP - 464
EP - 473
JO - Experientia
JF - Experientia
IS - 5
ER -