The major histocompatibility complex influences the ethiopathogenesis of MS-like disease in primates at multiple levels

B A 't Hart, H P Brok, S Amor, R E Bontrop

Research output: Contribution to journalReview articleAcademicpeer-review

19 Citations (Scopus)


Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease primarily affecting the central nervous system. Of the many candidate polymorphic major histocompatibility complex (MHC) and non-MHC genes contributing to disease susceptibility, including those encoding effector (cytokines and chemokines) or receptor molecules within the immune system (MHC, TCR, Ig or FcR), human leukocyte antigen (HLA) class II genes have the most significant influence. In this article we put forward the hypothesis that the influence of HLA genes on the risk to develop MS is actually the sum of multiple antigen presenting cell (APC) and T-cell interactions involving HLA class I and class II molecules. This article will also discuss that, because of the genetic and immunologic similarity to humans, autoimmune models of MS in non-human primates are the experimental models "par excellence" to test this hypothesis.

Original languageEnglish
Pages (from-to)1371-81
Number of pages11
JournalHuman immunology
Issue number12
Publication statusPublished - Dec 2001


  • Animals
  • Antigen-Presenting Cells
  • Autoantibodies
  • Brain
  • Disease Models, Animal
  • Encephalomyelitis, Autoimmune, Experimental
  • Female
  • Humans
  • Journal Article
  • Major Histocompatibility Complex
  • Male
  • Mice
  • Multiple Sclerosis
  • Myelin Sheath
  • Research Support, Non-U.S. Gov't
  • Review
  • Risk Factors
  • T-Lymphocytes

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