TY - JOUR
T1 - The multifaceted actions of the lncRNA H19 in cardiovascular biology and diseases
AU - Busscher, Denise
AU - Boon, Reinier A.
AU - Juni, Rio P.
N1 - Funding Information: This work was supported by the European Research Council (ERC Consolidator “NICCA” to R.A.B.). Publisher Copyright: © 2022 The Author(s).
PY - 2022/8/12
Y1 - 2022/8/12
N2 - Cardiovascular diseases are the leading cause of death and debility worldwide. Various molecular mechanisms have been studied to better understand the development and progression of cardiovascular pathologies with hope to eradicate these diseases. With the advancement of the sequencing technology, it is revealed that the majority of our genome is non-coding. A growing body of literature demonstrates the critical role of long non-coding RNAs (lncRNAs) as epigenetic regulators of gene expression. LncRNAs can regulate cellular biological processes through various distinct molecular mechanisms. The abundance of lncRNAs in the cardiovascular system indicates their significance in cardiovascular physiology and pathology. LncRNA H19, in particular, is a highly evolutionarily conserved lncRNA that is enriched in cardiac and vascular tissue, underlining its importance in maintaining homeostasis of the cardiovascular system. In this review, we discuss the versatile function of H19 in various types of cardiovascular diseases. We highlight the current literature on H19 in the cardiovascular system and demonstrate how dysregulation of H19 induces the development of cardiovascular pathophysiology.
AB - Cardiovascular diseases are the leading cause of death and debility worldwide. Various molecular mechanisms have been studied to better understand the development and progression of cardiovascular pathologies with hope to eradicate these diseases. With the advancement of the sequencing technology, it is revealed that the majority of our genome is non-coding. A growing body of literature demonstrates the critical role of long non-coding RNAs (lncRNAs) as epigenetic regulators of gene expression. LncRNAs can regulate cellular biological processes through various distinct molecular mechanisms. The abundance of lncRNAs in the cardiovascular system indicates their significance in cardiovascular physiology and pathology. LncRNA H19, in particular, is a highly evolutionarily conserved lncRNA that is enriched in cardiac and vascular tissue, underlining its importance in maintaining homeostasis of the cardiovascular system. In this review, we discuss the versatile function of H19 in various types of cardiovascular diseases. We highlight the current literature on H19 in the cardiovascular system and demonstrate how dysregulation of H19 induces the development of cardiovascular pathophysiology.
KW - cardiovascular disease
KW - cardiovascular physiology
KW - large intervening non-coding RNA
KW - lncRNA H19
KW - non-coding RNA
UR - http://www.scopus.com/inward/record.url?scp=85136339857&partnerID=8YFLogxK
U2 - https://doi.org/10.1042/CS20210994
DO - https://doi.org/10.1042/CS20210994
M3 - Review article
C2 - 35946958
SN - 1470-8736
VL - 136
SP - 1157
EP - 1178
JO - Clinical science (London, England : 1979)
JF - Clinical science (London, England : 1979)
IS - 15
ER -