The nature of the cell cycle in neurons: focus on a "non-canonical" pathway of DNA replication causally related to death

Agata Copani; Filippo Caraci; Jeroen J M Hoozemans; Marco Calafiore; Maria Angela Sortino; Ferdinando Nicoletti

doi:https://doi.org/10.1016/j.bbadis.2006.10.016

The nature of the cell cycle in neurons: focus on a "non-canonical" pathway of DNA replication causally related to death

Agata Copani, Filippo Caraci, Jeroen J M Hoozemans, Marco Calafiore, Maria Angela Sortino, Ferdinando Nicoletti

Research output: Contribution to journal › Article › Academic › peer-review

49 Citations (Scopus)

Abstract

The mechanism whereby a reactivation of cell cycle in neurons causes cell death is beginning to be identified. In cellular models of Alzheimer's disease, activation of a non-canonical pathway of DNA replication contributes to neuronal death. This pathway involves the repair enzyme DNA polymerase-beta, which is highly expressed in neurons of the Alzheimer's brain at early stages of the disease. Loading of DNA polymerase-beta into the replication forks generates a death signal, which involves the tumor suppressor p53. The increasing knowledge of the main actors of the unscheduled DNA replication in neurons will pave the way for novel therapeutic interventions in Alzheimer's disease and other neurodegenerative disorders.

Original language	English
Pages (from-to)	409-12
Number of pages	4
Journal	Biochimica et Biophysica Acta. Reviews on Cancer
Volume	1772
Issue number	4
DOIs	https://doi.org/10.1016/j.bbadis.2006.10.016
Publication status	Published - Apr 2007

Keywords

Alzheimer Disease
Animals
Brain
Cell Cycle
Cell Death
DNA Replication
Humans
Journal Article
Nerve Degeneration
Neurons
Review

Access to Document

https://doi.org/10.1016/j.bbadis.2006.10.016

Cite this

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abstract = "The mechanism whereby a reactivation of cell cycle in neurons causes cell death is beginning to be identified. In cellular models of Alzheimer's disease, activation of a non-canonical pathway of DNA replication contributes to neuronal death. This pathway involves the repair enzyme DNA polymerase-beta, which is highly expressed in neurons of the Alzheimer's brain at early stages of the disease. Loading of DNA polymerase-beta into the replication forks generates a death signal, which involves the tumor suppressor p53. The increasing knowledge of the main actors of the unscheduled DNA replication in neurons will pave the way for novel therapeutic interventions in Alzheimer's disease and other neurodegenerative disorders.",

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AU - Sortino, Maria Angela

AU - Nicoletti, Ferdinando

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