The potential role of thrombopoietin in idiopathic thrombocytopenic purpura

A. von dem Borne; C. Folman; S. van den Oudenrijn; G. Linthorst; S. de Jong; M. de Haas

doi:https://doi.org/10.1054/blre.2001.0184

The potential role of thrombopoietin in idiopathic thrombocytopenic purpura

A. von dem Borne, C. Folman, S. van den Oudenrijn, G. Linthorst, S. de Jong, M. de Haas

Research output: Contribution to journal › Review article › Academic › peer-review

15 Citations (Scopus)

Abstract

Thrombopoietin (TPO) plays a central role in the pathogenesis of idiopathic thrombocytopenic purpura (ITP), as it does in other immune-mediated thrombocytopenias. Because TPO is bound and internalized by platelets, it is destroyed together with platelets at an accelerated rate in the macrophage system. Because the spleen acts as a TPO sink, compensation of the decreased platelet count by an increased production in the bone marrow is insufficient. This aspect of ITP, as well as the use of TPO in the treatment of ITP, will be the focus of this article. (C) 2002, Elsevier Science Ltd. All rights reserved

Original language	English
Pages (from-to)	57-59
Journal	Blood Reviews
Volume	16
Issue number	1
DOIs	https://doi.org/10.1054/blre.2001.0184
Publication status	Published - 2002

Access to Document

https://doi.org/10.1054/blre.2001.0184

Cite this

@article{31cadcb5006045c5a2ac39155bd9f14b,

title = "The potential role of thrombopoietin in idiopathic thrombocytopenic purpura",

abstract = "Thrombopoietin (TPO) plays a central role in the pathogenesis of idiopathic thrombocytopenic purpura (ITP), as it does in other immune-mediated thrombocytopenias. Because TPO is bound and internalized by platelets, it is destroyed together with platelets at an accelerated rate in the macrophage system. Because the spleen acts as a TPO sink, compensation of the decreased platelet count by an increased production in the bone marrow is insufficient. This aspect of ITP, as well as the use of TPO in the treatment of ITP, will be the focus of this article. (C) 2002, Elsevier Science Ltd. All rights reserved",

author = "{von dem Borne}, A. and C. Folman and {van den Oudenrijn}, S. and G. Linthorst and {de Jong}, S. and {de Haas}, M.",

year = "2002",

doi = "https://doi.org/10.1054/blre.2001.0184",

language = "English",

volume = "16",

pages = "57--59",

journal = "Blood Reviews",

issn = "0268-960X",

publisher = "Churchill Livingstone",

number = "1",

}

TY - JOUR

T1 - The potential role of thrombopoietin in idiopathic thrombocytopenic purpura

AU - von dem Borne, A.

AU - Folman, C.

AU - van den Oudenrijn, S.

AU - Linthorst, G.

AU - de Jong, S.

AU - de Haas, M.

PY - 2002

Y1 - 2002

N2 - Thrombopoietin (TPO) plays a central role in the pathogenesis of idiopathic thrombocytopenic purpura (ITP), as it does in other immune-mediated thrombocytopenias. Because TPO is bound and internalized by platelets, it is destroyed together with platelets at an accelerated rate in the macrophage system. Because the spleen acts as a TPO sink, compensation of the decreased platelet count by an increased production in the bone marrow is insufficient. This aspect of ITP, as well as the use of TPO in the treatment of ITP, will be the focus of this article. (C) 2002, Elsevier Science Ltd. All rights reserved

AB - Thrombopoietin (TPO) plays a central role in the pathogenesis of idiopathic thrombocytopenic purpura (ITP), as it does in other immune-mediated thrombocytopenias. Because TPO is bound and internalized by platelets, it is destroyed together with platelets at an accelerated rate in the macrophage system. Because the spleen acts as a TPO sink, compensation of the decreased platelet count by an increased production in the bone marrow is insufficient. This aspect of ITP, as well as the use of TPO in the treatment of ITP, will be the focus of this article. (C) 2002, Elsevier Science Ltd. All rights reserved

U2 - https://doi.org/10.1054/blre.2001.0184

DO - https://doi.org/10.1054/blre.2001.0184

M3 - Review article

C2 - 11913997

SN - 0268-960X

VL - 16

SP - 57

EP - 59

JO - Blood Reviews

JF - Blood Reviews

IS - 1

ER -