@inbook{e79f73cf1de5483d8b0cfb0c58e952bf,
title = "The prediction of preoperative decline in nutritional status during chemo-radiation therapy in patients with esophageal cancer",
abstract = "Rationale: Patients with esophageal cancer are at high risk for developing malnutrition during neo-adjuvant chemo-radiation therapy (NA-CRTh), which in turn is associated with postoperative morbidity. The aim of this study was to identify which pre-treatment parameters were predictive for a decline in nutritional status during NA-CRTh. Methods: In this prospective study, 87 patients with esophageal cancer treated with NA-CRTh were included. Age, gender, % weight change, body mass index (kg/m2), fat (free) mass index (kg/m2), phase angle (°), handgrip strength (kg), energy (%EI)- and protein intake (%PI) as % of requirements, tumor classification and performance score were measured. A prediction model was constructed to analyze which of these parameters predicted a decline in nutritional status (defined as weight loss of >5% and/or decline in fat free mass of ≥1,4 kg) during NA-CRTh. Results: Nutritional status declined in 36% of the patients during NA-CRTh. Main predictors were a higher phase angle (OR 1.76 (95% CI 1.05-2.94)) and a lower %PI (OR 0.97 (95% CI 0.94- 0.99)). The prediction formula was defined as: -1.486 + 0.566∗PA-0.035∗%PI. This indicates for example a 55% chance to decline in nutritional status during NA-CRTh in a patient with a phase angle of 6 and %PI of 50%. Quality of the prediction model was tested by the Hosmer and Lemeshow test (p = 0.97). The ROC-AUC was 0.70 (95% CI 0.58-0.81). Conclusion: Results of this study suggest that patients in a good nutritional status (i.e. higher phase angle) but with a poor nutritional intake (i.e. lower %PI) are at highest risk to decline in nutritional status during NA-CRTh. This give opportunities for targeted dietetic care in patients with esophageal cancer who receive NA-CRTh.",
keywords = "body mass, body weight loss, chemoradiotherapy, controlled study, disease model, esophagus cancer, fat free mass, female, gender, grip strength, human, major clinical study, male, nutritional status, prediction, prospective study, protein intake, radiotherapy, tumor classification",
author = "Rietveld, {S C} and Witvliet, {J E} and K Ottens-Oussoren and {Van Der Peet}, {D L} and {De Van Der Schueren}, {M A}",
year = "2016",
language = "English",
isbn = "1532-1983",
series = "Clinical Nutrition",
pages = "S184",
booktitle = "Clinical Nutrition",
}