@article{599908feb592412bafb1095de6e54633,
title = "The prescriber's guide to classic MAO-inhibitors (phenelzine, tranylcypromine, isocarboxazid) for treatment-resistant depression",
abstract = "This article is a clinical guide which discusses the state-of-The-Art usage of the classic MAOI antidepressants (phenelzine, tranylcypromine, and isocarboxazid) in modern psychiatric practice. The guide is for all clinicians, including those who may not be experienced MAOI-prescribers. It discusses indications, drug drug interactions, side-effect management, and the safety of various augmentation strategies. There is a clear and broad consensus (over 70 international expert129 endorsers), based on six decades of experience, for the recommendations herein exposited. They are based on empirical evidence and on expert opinion this guide is presented as a new specialist131 consensus standard. The guide provides practical clinical advice, and is the basis for the rational use of these drugs, particularly because it improves and updates knowledge, and corrects the various misconceptions that have hitherto been prominent in the literature, partly due to insufficient knowledge of pharmacology. The guide suggests that MAOIs should always be considered in cases of treatment-resistant depression (including those melancholic in nature), and prior to ECT whilst taking account of patient preference. In selected cases, they may be considered earlier in the treatment algorithm than has previously been customary, and should not be regarded as drugs of last resort; they may prove decisively effective when many other treatments have failed. The guide clarifies key points on the concomitant use of incorrectly proscribed drugs such as methylphenidate and some TCAs. It also illustrates the straightforward bridging methods that may be used to transition simply and safely from other antidepressants to MAOIs.",
keywords = "Isocarboxazid, MAOI, Monoamine oxidase inhibitor, Phenelzine, Tranylcypromine, Treatment-resistant depression, classic MAOI",
author = "{van den Eynde}, Vincent and Abdelmoemin, {Wegdan R.} and Abraham, {Magid M.} and Amsterdam, {Jay D.} and Anderson, {Ian M.} and Chittaranjan Andrade and Baker, {Glen B.} and Beekman, {Aartjan T. F.} and Michael Berk and Birkenh{\"a}ger, {Tom K.} and Blackwell, {Barry B.} and Pierre Blier and Blom, {Marc B. J.} and Bodkin, {J. Alexander} and Cattaneo, {Carlo Ignazio} and Bezalel Dantz and Jonathan Davidson and Dunlop, {Boadie W.} and Est{\'e}vez, {Ryan F.} and Feinberg, {S. Shalom} and Finberg, {John P. M.} and Fochtmann, {Laura J.} and David Gotlib and Andrew Holt and Insel, {Thomas R.} and Larsen, {Jens Knud} and Rajnish Mago and Menkes, {David B.} and Meyer, {Jonathan M.} and Nutt, {David J.} and Gordon Parker and Rego, {Mark D.} and Elliott Richelson and Ruh{\'e}, {Henricus G.} and Jer{\'o}nimo S{\'a}iz-Ruiz and Stahl, {Stephen M.} and Thomas Steele and Thase, {Michael E.} and Sven Ulrich and {van Balkom}, {Anton J. L. M.} and Eduard Vieta and Ian Whyte and Young, {Allan H.} and Gillman, {Peter Kenneth}",
note = "Publisher Copyright: {\textcopyright} 2022 Cambridge University Press. All rights reserved.",
year = "2023",
month = aug,
day = "15",
doi = "https://doi.org/10.1017/S1092852922000906",
language = "English",
volume = "28",
pages = "427--440",
journal = "CNS spectrums",
issn = "1092-8529",
publisher = "MBL Communications",
number = "4",
}