TY - JOUR
T1 - The prevalence and related factors of fatigue in patients with copd: A systematic review
AU - Ebadi, Zjala
AU - Goërtz, Yvonne M. J.
AU - Herck, Maarten Van
AU - Janssen, Daisy J. A.
AU - Spruit, Martijn A.
AU - Burtin, Chris
AU - Thong, Melissa S. Y.
AU - Muris, Jean
AU - Otker, Jacqueline
AU - Looijmans, Milou
AU - Vlasblom, Christel
AU - Bastiaansen, Joëlle
AU - Prins, Judith
AU - Wouters, Emiel F. M.
AU - Vercoulen, Jan H.
AU - Peters, Jeannette B.
N1 - Funding Information: Conflict of interest: Z. Ebadi has nothing to disclose. M.J. Goërtz has nothing to disclose. M. Van Herck has nothing to disclose. D.A.J. Janssen reports personal fees from Novartis, Boehringer Ingelheim and AstraZeneca, outside the submitted work. M.A. Spruit reports grants from Netherlands Lung Foundation, Stichting Astma Bestrijding, Boehringer Ingelheim and AstraZeneca, during the conduct of the study; and personal fees from Boehringer Ingelheim and AstraZeneca, outside the submitted work. C. Burtin has nothing to disclose. M.S.Y. Thong has nothing to disclose. J. Muris has nothing to disclose. J. Otker has nothing to disclose. M. Looijmans has nothing to disclose. C. Vlasblom has nothing to disclose. J. Bastiaansen has nothing to disclose. J. Prins has nothing to disclose. E.F.M. Wouters has nothing to disclose. J.H. Vercoulen has nothing to disclose. J.B. Peters has nothing to disclose. Funding Information: Support statement: This project is supported by grant 4.1.16.085 of Lung Foundation Netherlands (Leusden, The Netherlands), AstraZeneca Netherlands, Boehringer Ingelheim Netherlands and Stichting Astma Bestrijding (Amsterdam, The Netherlands). Funding information for this article has been deposited with the Crossref Funder Registry. Publisher Copyright: © The authors 2021. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021
Y1 - 2021
N2 - Background Fatigue is a distressing symptom in patients with COPD. Little is known about the factors that contribute to fatigue in COPD. This review summarises existing knowledge on the prevalence of fatigue, factors related to fatigue and the instruments most commonly used to assess fatigue in COPD. Methods Pubmed, PsycINFO, EMBASE, Cochrane and CINAHL databases were searched for studies from inception up to 7 January 2020 using the medical subject headings “COPD” and “Fatigue”. Studies were reviewed in accordance with PRISMA guidelines. Results 196 studies were evaluated. The prevalence of fatigue ranged from 17–95%. Age (r=−0.23 to r=0.27), sex (r=0.11), marital status (r=−0.096), dyspnoea (r=0.13 to r=0.78), forced expiatory volume in 1 s % predicted (r=−0.55 to r=−0.076), number of exacerbations (r=0.27 to r=0.38), number of comorbidities (r=0.10), number of medications (r=0.35), anxiety (r=0.36 to r=0.61), depression (r=0.41 to r=0.66), muscle strength (r=−0.78 to r=−0.45), functional capacity (r=−0.77 to r=−0.14) and quality of life (r=0.48 to r=0.77) showed significant associations with fatigue. Conclusions Fatigue is a prevalent symptom in patients with COPD. Multiple physical and psychological factors seem to be associated with fatigue. Future studies are needed to evaluate these underlying factors in integral analyses in samples of patients with COPD.
AB - Background Fatigue is a distressing symptom in patients with COPD. Little is known about the factors that contribute to fatigue in COPD. This review summarises existing knowledge on the prevalence of fatigue, factors related to fatigue and the instruments most commonly used to assess fatigue in COPD. Methods Pubmed, PsycINFO, EMBASE, Cochrane and CINAHL databases were searched for studies from inception up to 7 January 2020 using the medical subject headings “COPD” and “Fatigue”. Studies were reviewed in accordance with PRISMA guidelines. Results 196 studies were evaluated. The prevalence of fatigue ranged from 17–95%. Age (r=−0.23 to r=0.27), sex (r=0.11), marital status (r=−0.096), dyspnoea (r=0.13 to r=0.78), forced expiatory volume in 1 s % predicted (r=−0.55 to r=−0.076), number of exacerbations (r=0.27 to r=0.38), number of comorbidities (r=0.10), number of medications (r=0.35), anxiety (r=0.36 to r=0.61), depression (r=0.41 to r=0.66), muscle strength (r=−0.78 to r=−0.45), functional capacity (r=−0.77 to r=−0.14) and quality of life (r=0.48 to r=0.77) showed significant associations with fatigue. Conclusions Fatigue is a prevalent symptom in patients with COPD. Multiple physical and psychological factors seem to be associated with fatigue. Future studies are needed to evaluate these underlying factors in integral analyses in samples of patients with COPD.
UR - http://www.scopus.com/inward/record.url?scp=85104389348&partnerID=8YFLogxK
U2 - https://doi.org/10.1183/16000617.0298-2020
DO - https://doi.org/10.1183/16000617.0298-2020
M3 - Review article
C2 - 33853886
SN - 0905-9180
VL - 30
JO - European Respiratory Review
JF - European Respiratory Review
IS - 160
M1 - 200298
ER -