TY - JOUR
T1 - The risk of tooth loss in patients with diabetes
T2 - A systematic review and meta-analysis
AU - Weijdijk, Lotte P.M.
AU - Ziukaite, Laura
AU - Van der Weijden, G. A.
AU - Bakker, Eric W.P.
AU - Slot, Dagmar Else
N1 - Funding Information: This research received no specific grant from any funding agency in the public, commercial or not‐for‐profit sectors. For this study, no funding was accepted, except for support from the listed institution as work for this paper is funded by a regular academic appointment at the Academic Center for Dentistry Amsterdam (ACTA) of Slot and Van der Weijden And Bakker at University of Amsterdam, Amsterdam. Publisher Copyright: © 2021 The Authors. International Journal of Dental Hygiene published by John Wiley & Sons Ltd.
PY - 2022/2
Y1 - 2022/2
N2 - Aim: The aim of this systematic review was to comprehensively and critically summarize and synthesize the risk of losing teeth among with diabetes mellitus (DM) compared to those without DM, as established in observational studies. Materials and methods: MEDLINE-PubMed and Cochrane databases were searched through a period from their inception through October 2020 to identify eligible studies. Papers that primarily evaluate the number of teeth in DM patients compared to non-DM individuals were included. A descriptive analysis of the selected studies was conducted, and when feasible, a meta-analysis was performed. The quality of the studies was assessed. Results: A total of 1087 references were generated, and screening of the papers resulted in 10 eligible publications. A descriptive analysis demonstrated that six of these studies indicate a significantly higher risk of tooth loss in DM patients. This was confirmed by the meta-analysis risk ratio of 1.63 95% CI (1.33; 2.00, p < 0.00001). Subgroup analysis illustrates that this is irrespective of the risk-of-bias assessment. The higher risk of tooth loss in DM patients was also higher when only DM type II patients or studies with a cross-sectional design were considered. Patients with a poor DM control status presented a significantly increased risk of tooth loss. When the data were separated by the world continent where the study was performed, Asia and South America had numerically higher risks and a 95% CI that did not overlap with Europe and North America. Conclusion: There is moderate certainty for a small but significantly higher risk of tooth loss in DM patients as compared to those without DM.
AB - Aim: The aim of this systematic review was to comprehensively and critically summarize and synthesize the risk of losing teeth among with diabetes mellitus (DM) compared to those without DM, as established in observational studies. Materials and methods: MEDLINE-PubMed and Cochrane databases were searched through a period from their inception through October 2020 to identify eligible studies. Papers that primarily evaluate the number of teeth in DM patients compared to non-DM individuals were included. A descriptive analysis of the selected studies was conducted, and when feasible, a meta-analysis was performed. The quality of the studies was assessed. Results: A total of 1087 references were generated, and screening of the papers resulted in 10 eligible publications. A descriptive analysis demonstrated that six of these studies indicate a significantly higher risk of tooth loss in DM patients. This was confirmed by the meta-analysis risk ratio of 1.63 95% CI (1.33; 2.00, p < 0.00001). Subgroup analysis illustrates that this is irrespective of the risk-of-bias assessment. The higher risk of tooth loss in DM patients was also higher when only DM type II patients or studies with a cross-sectional design were considered. Patients with a poor DM control status presented a significantly increased risk of tooth loss. When the data were separated by the world continent where the study was performed, Asia and South America had numerically higher risks and a 95% CI that did not overlap with Europe and North America. Conclusion: There is moderate certainty for a small but significantly higher risk of tooth loss in DM patients as compared to those without DM.
KW - diabetes mellitus
KW - number of teeth
KW - oral health
KW - risk ratio
KW - systematic review
KW - tooth loss
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U2 - https://doi.org/10.1111/idh.12512
DO - https://doi.org/10.1111/idh.12512
M3 - Review article
C2 - 33973353
SN - 1601-5029
VL - 20
SP - 145
EP - 166
JO - International journal of dental hygiene
JF - International journal of dental hygiene
IS - 1
ER -
