The road to residency: Uncovering the proteome, metabolism and transcriptional networks of tissue-resident memory T cells

CD8+ memory T cells persist after infection as circulating and resident subsets to increase the capacity of the immune system to eradicate viruses and other intracellular pathogens upon secondary encounter. The ability of memory CD8+ T cells to retain their proliferative potential and to differentiate into effectors are characteristics that can be exploited for their in vitro expansion into