The role of BRD7 in embryo development and glucose metabolism

Yoo Kim; Mario Andrés Salazar Hernández; Hilde Herrema; Tuncay Delibasi; Sang Won Park

doi:https://doi.org/10.1111/jcmm.12907

The role of BRD7 in embryo development and glucose metabolism

Yoo Kim, Mario Andrés Salazar Hernández, Hilde Herrema, Tuncay Delibasi, Sang Won Park

Research output: Contribution to journal › Article › Academic › peer-review

14 Citations (Scopus)

Abstract

Bromodomain-containing protein 7 (BRD7) is a member of bromodomain-containing protein family and its function has been implicated in several diseases. We have previously shown that BRD7 plays a role in metabolic processes. However, the effect of BRD7 deficiency in glucose metabolism and its role in in vivo have not been fully revealed. Here, we report the essential role of BRD7 during embryo development. Mice homozygous for BRD7 led to embryonic lethality at mid-gestation. Homozygous BRD7 knockout (KO) mice showed retardation in development, and eventually all BRD7 KO embryos died in utero prior to E16.5. Partial knockdown of Brd7 gene displayed mild changes in glucose metabolism.

Original language	English
Pages (from-to)	1561-70
Number of pages	10
Journal	Journal of cellular and molecular medicine
Volume	20
Issue number	8
DOIs	https://doi.org/10.1111/jcmm.12907
Publication status	Published - Aug 2016
Externally published	Yes

Keywords

Adenoviridae/metabolism
Animals
Chromosomal Proteins, Non-Histone/genetics
Crosses, Genetic
Diet, High-Fat
Embryo Loss/genetics
Embryonic Development/drug effects
Female
Gene Deletion
Gene Expression Regulation, Developmental/drug effects
Gene Knockdown Techniques
Glucose/metabolism
Heterozygote
Homeostasis/drug effects
Insulin/pharmacology
Liver/metabolism
Male
Mice, Knockout
Pregnancy
RNA, Messenger/genetics
RNA, Small Interfering/metabolism

Access to Document

https://doi.org/10.1111/jcmm.12907

Cite this

@article{b78765d1b3ba45719b8586791c7533a8,

title = "The role of BRD7 in embryo development and glucose metabolism",

abstract = "Bromodomain-containing protein 7 (BRD7) is a member of bromodomain-containing protein family and its function has been implicated in several diseases. We have previously shown that BRD7 plays a role in metabolic processes. However, the effect of BRD7 deficiency in glucose metabolism and its role in in vivo have not been fully revealed. Here, we report the essential role of BRD7 during embryo development. Mice homozygous for BRD7 led to embryonic lethality at mid-gestation. Homozygous BRD7 knockout (KO) mice showed retardation in development, and eventually all BRD7 KO embryos died in utero prior to E16.5. Partial knockdown of Brd7 gene displayed mild changes in glucose metabolism.",

keywords = "Adenoviridae/metabolism, Animals, Chromosomal Proteins, Non-Histone/genetics, Crosses, Genetic, Diet, High-Fat, Embryo Loss/genetics, Embryonic Development/drug effects, Female, Gene Deletion, Gene Expression Regulation, Developmental/drug effects, Gene Knockdown Techniques, Glucose/metabolism, Heterozygote, Homeostasis/drug effects, Insulin/pharmacology, Liver/metabolism, Male, Mice, Knockout, Pregnancy, RNA, Messenger/genetics, RNA, Small Interfering/metabolism",

author = "Yoo Kim and {Andr{\'e}s Salazar Hern{\'a}ndez}, Mario and Hilde Herrema and Tuncay Delibasi and Park, {Sang Won}",

note = "{\textcopyright} 2016 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.",

year = "2016",

month = aug,

doi = "https://doi.org/10.1111/jcmm.12907",

language = "English",

volume = "20",

pages = "1561--70",

journal = "Journal of cellular and molecular medicine",

issn = "1582-1838",

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TY - JOUR

T1 - The role of BRD7 in embryo development and glucose metabolism

AU - Kim, Yoo

AU - Andrés Salazar Hernández, Mario

AU - Herrema, Hilde

AU - Delibasi, Tuncay

AU - Park, Sang Won

PY - 2016/8

Y1 - 2016/8

N2 - Bromodomain-containing protein 7 (BRD7) is a member of bromodomain-containing protein family and its function has been implicated in several diseases. We have previously shown that BRD7 plays a role in metabolic processes. However, the effect of BRD7 deficiency in glucose metabolism and its role in in vivo have not been fully revealed. Here, we report the essential role of BRD7 during embryo development. Mice homozygous for BRD7 led to embryonic lethality at mid-gestation. Homozygous BRD7 knockout (KO) mice showed retardation in development, and eventually all BRD7 KO embryos died in utero prior to E16.5. Partial knockdown of Brd7 gene displayed mild changes in glucose metabolism.

AB - Bromodomain-containing protein 7 (BRD7) is a member of bromodomain-containing protein family and its function has been implicated in several diseases. We have previously shown that BRD7 plays a role in metabolic processes. However, the effect of BRD7 deficiency in glucose metabolism and its role in in vivo have not been fully revealed. Here, we report the essential role of BRD7 during embryo development. Mice homozygous for BRD7 led to embryonic lethality at mid-gestation. Homozygous BRD7 knockout (KO) mice showed retardation in development, and eventually all BRD7 KO embryos died in utero prior to E16.5. Partial knockdown of Brd7 gene displayed mild changes in glucose metabolism.

KW - Adenoviridae/metabolism

KW - Animals

KW - Chromosomal Proteins, Non-Histone/genetics

KW - Crosses, Genetic

KW - Diet, High-Fat

KW - Embryo Loss/genetics

KW - Embryonic Development/drug effects

KW - Female

KW - Gene Deletion

KW - Gene Expression Regulation, Developmental/drug effects

KW - Gene Knockdown Techniques

KW - Glucose/metabolism

KW - Heterozygote

KW - Homeostasis/drug effects

KW - Insulin/pharmacology

KW - Liver/metabolism

KW - Male

KW - Mice, Knockout

KW - Pregnancy

KW - RNA, Messenger/genetics

KW - RNA, Small Interfering/metabolism

U2 - https://doi.org/10.1111/jcmm.12907

DO - https://doi.org/10.1111/jcmm.12907

M3 - Article

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SN - 1582-1838

VL - 20

SP - 1561

EP - 1570

JO - Journal of cellular and molecular medicine

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IS - 8

ER -