The Role of Platelets in Diabetic Kidney Disease

Ukhti Jamil Rustiasari; Joris J. Roelofs

doi:https://doi.org/10.3390/ijms23158270

The Role of Platelets in Diabetic Kidney Disease

Ukhti Jamil Rustiasari, Joris J. Roelofs

Research output: Contribution to journal › Review article › Academic › peer-review

10 Citations (Scopus)

Abstract

Diabetic kidney disease (DKD) is among the most common microvascular complications in patients with diabetes, and it currently accounts for the majority of end-stage kidney disease cases worldwide. The pathogenesis of DKD is complex and multifactorial, including systemic and intra-renal inflammatory and coagulation processes. Activated platelets play a pivotal role in inflammation, coagulation, and fibrosis. Mounting evidence shows that platelets play a role in the pathogenesis and progression of DKD. The potentially beneficial effects of antiplatelet agents in preventing progression of DKD has been studied in animal models and clinical trials. This review summarizes the current knowledge on the role of platelets in DKD, including the potential therapeutic effects of antiplatelet therapies.

Original language	English
Article number	8270
Journal	International journal of molecular sciences
Volume	23
Issue number	15
DOIs	https://doi.org/10.3390/ijms23158270
Publication status	Published - Aug 2022

Keywords

antiplatelet
biomarker
diabetes
diabetic kidney disease
diabetic nephropathy
platelet activation
platelets

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https://doi.org/10.3390/ijms23158270

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title = "The Role of Platelets in Diabetic Kidney Disease",

abstract = "Diabetic kidney disease (DKD) is among the most common microvascular complications in patients with diabetes, and it currently accounts for the majority of end-stage kidney disease cases worldwide. The pathogenesis of DKD is complex and multifactorial, including systemic and intra-renal inflammatory and coagulation processes. Activated platelets play a pivotal role in inflammation, coagulation, and fibrosis. Mounting evidence shows that platelets play a role in the pathogenesis and progression of DKD. The potentially beneficial effects of antiplatelet agents in preventing progression of DKD has been studied in animal models and clinical trials. This review summarizes the current knowledge on the role of platelets in DKD, including the potential therapeutic effects of antiplatelet therapies.",

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author = "Rustiasari, {Ukhti Jamil} and Roelofs, {Joris J.}",

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AU - Rustiasari, Ukhti Jamil

AU - Roelofs, Joris J.

N1 - Funding Information: This study was supported by the Indonesia Directorate General of Higher Education (BPP-LN DIKTI), Ministry of Education, Culture, Research, and Technology of the Republic of Indonesia for PhD program scholarship. Publisher Copyright: © 2022 by the authors.

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N2 - Diabetic kidney disease (DKD) is among the most common microvascular complications in patients with diabetes, and it currently accounts for the majority of end-stage kidney disease cases worldwide. The pathogenesis of DKD is complex and multifactorial, including systemic and intra-renal inflammatory and coagulation processes. Activated platelets play a pivotal role in inflammation, coagulation, and fibrosis. Mounting evidence shows that platelets play a role in the pathogenesis and progression of DKD. The potentially beneficial effects of antiplatelet agents in preventing progression of DKD has been studied in animal models and clinical trials. This review summarizes the current knowledge on the role of platelets in DKD, including the potential therapeutic effects of antiplatelet therapies.

AB - Diabetic kidney disease (DKD) is among the most common microvascular complications in patients with diabetes, and it currently accounts for the majority of end-stage kidney disease cases worldwide. The pathogenesis of DKD is complex and multifactorial, including systemic and intra-renal inflammatory and coagulation processes. Activated platelets play a pivotal role in inflammation, coagulation, and fibrosis. Mounting evidence shows that platelets play a role in the pathogenesis and progression of DKD. The potentially beneficial effects of antiplatelet agents in preventing progression of DKD has been studied in animal models and clinical trials. This review summarizes the current knowledge on the role of platelets in DKD, including the potential therapeutic effects of antiplatelet therapies.

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KW - biomarker

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KW - diabetic nephropathy

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The Role of Platelets in Diabetic Kidney Disease

Abstract

Keywords

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