The role of transforming growth factor beta in bicuspid aortic valve aortopathy

Nimrat Grewal, Onur Dolmaci, Arthur Klautz, Juno Legue, Antoine Driessen, Robert Klautz, Robert Poelmann

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

A bicuspid aortic valve (BAV) is the most prevalent congenital cardiac deformity, which is associated with an increased risk to develop a thoracic aortic aneurysm and/or an aortic dissection as compared to persons with a tricuspid aortic valve. Due to the high prevalence of a BAV in the general population and the associated life-long increased risk for adverse vascular events, BAV disease places a considerable burden on the public health. The aim of the present review is to discuss the role of transforming growth factor beta (TGF-β) signaling in the development of the vascular wall and on how this complex signaling pathway may be involved in thoracic aortic aneurysm formation in tricuspid and BAV patients.
Original languageEnglish
Pages (from-to)270-279
Number of pages10
JournalIndian Journal of Thoracic and Cardiovascular Surgery
Volume39
Early online date2023
DOIs
Publication statusPublished - Dec 2023

Keywords

  • Bicuspid aortic valve
  • Embryology
  • Molecular biology
  • TGF-β
  • Thoracic aortopathy

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