TY - JOUR
T1 - The role of uterine natural killer cells in recurrent pregnancy loss and possible treatment options
AU - Béquet, Yentl Louise Betty Nel
AU - Lashley, Eileen Elisabeth Lynn O. neill
AU - Goddijn, Mariette
AU - van der Hoorn, Marie-Louise Petronella
N1 - Publisher Copyright: © 2023 The Authors
PY - 2023/11
Y1 - 2023/11
N2 - This narrative review summarizes the current knowledge on the role of uterine natural killer (uNK) cells in recurrent pregnancy loss and possible treatment options. Recurrent pregnancy loss involves 2 or more consecutive miscarriages, affecting around 3% of couples attempting conception. Despite extensive investigation, causes often remain elusive. Uterine natural killer cells, critical in early gestation and implantation, may hold answers for treatment options. Properly designed and powered clinical trials are needed to provide more answers on the effect of treatment options in relation to uNK cells.
AB - This narrative review summarizes the current knowledge on the role of uterine natural killer (uNK) cells in recurrent pregnancy loss and possible treatment options. Recurrent pregnancy loss involves 2 or more consecutive miscarriages, affecting around 3% of couples attempting conception. Despite extensive investigation, causes often remain elusive. Uterine natural killer cells, critical in early gestation and implantation, may hold answers for treatment options. Properly designed and powered clinical trials are needed to provide more answers on the effect of treatment options in relation to uNK cells.
KW - Recurrent pregnancy loss
KW - reproductive immunology
KW - treatment strategies
KW - uNK cells
KW - uterine natural killer cells
UR - http://www.scopus.com/inward/record.url?scp=85173187457&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.fertnstert.2023.08.949
DO - https://doi.org/10.1016/j.fertnstert.2023.08.949
M3 - Review article
C2 - 37640099
SN - 0015-0282
VL - 120
SP - 945
EP - 947
JO - Fertility and Sterility
JF - Fertility and Sterility
IS - 5
ER -