Abstract
The alleged selective, high efficacy dopamine D1 receptor agonist, SKF 81297 (0.05-0.3 mg/kg i.m.), induced rotational behaviour away from the lesion and stimulated use of the dominant right hand in unilaterally (left side) 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned rhesus monkeys (Macaca mulatta). The effects of SKF 81297 were completely blocked by the dopamine D1 receptor antagonist, SCH 23390 (0.05 mg/kg), but not by the dopamine D2 receptor antagonist, remoxipride (1 mg/kg), and were similar to those induced by the selective dopamine D2 agonist, LY 171555 (0.01 mg/kg). These results suggest a functional stimulatory role for the dopamine D1 receptor on motor behaviour in a non-human primate model of Parkinson's disease when stimulated with a high efficacy selective dopamine D1 receptor agonist.
Original language | English |
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Pages (from-to) | 143-7 |
Number of pages | 5 |
Journal | European journal of pharmacology |
Volume | 235 |
Issue number | 1 |
Publication status | Published - 22 Apr 1993 |
Keywords
- Analysis of Variance
- Animals
- Benzazepines
- Disease Models, Animal
- Dopamine Agents
- Ergolines
- Journal Article
- MPTP Poisoning
- Macaca mulatta
- Male
- Motor Activity
- Parkinson Disease
- Quinpirole
- Remoxipride
- Research Support, Non-U.S. Gov't