The sterile immune response during hepatic ischemia/reperfusion

Rowan F. van Golen; Thomas M. van Gulik; Michal Heger

doi:https://doi.org/10.1016/j.cytogfr.2012.04.006

The sterile immune response during hepatic ischemia/reperfusion

Rowan F. van Golen, Thomas M. van Gulik, Michal Heger

Research output: Contribution to journal › Review article › Academic › peer-review

142 Citations (Scopus)

Abstract

Hepatic ischemia and reperfusion elicits an immune response that lacks a microbial constituent yet poses a potentially lethal threat to the host. In this sterile setting, the immune system is alarmed by endogenous danger signals that are release by stressed and dying liver cells. The detection of these immunogenic messengers by sentinel leukocyte populations constitutes the proximal trigger for a self-perpetuating cycle of inflammation, in which consecutive waves of cytokines and chemokines orchestrate the influx of various leukocyte subsets that ultimately confer tissue destruction. This review focuses on the temporal organization of sterile hepatic inflammation, using surgery-induced trauma as a template disease state. (C) 2012 Elsevier Ltd. All rights reserved

Original language	English
Pages (from-to)	69-84
Journal	Cytokine & Growth Factor Reviews
Volume	23
Issue number	3
DOIs	https://doi.org/10.1016/j.cytogfr.2012.04.006
Publication status	Published - 2012

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https://doi.org/10.1016/j.cytogfr.2012.04.006

Cite this

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title = "The sterile immune response during hepatic ischemia/reperfusion",

abstract = "Hepatic ischemia and reperfusion elicits an immune response that lacks a microbial constituent yet poses a potentially lethal threat to the host. In this sterile setting, the immune system is alarmed by endogenous danger signals that are release by stressed and dying liver cells. The detection of these immunogenic messengers by sentinel leukocyte populations constitutes the proximal trigger for a self-perpetuating cycle of inflammation, in which consecutive waves of cytokines and chemokines orchestrate the influx of various leukocyte subsets that ultimately confer tissue destruction. This review focuses on the temporal organization of sterile hepatic inflammation, using surgery-induced trauma as a template disease state. (C) 2012 Elsevier Ltd. All rights reserved",

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AB - Hepatic ischemia and reperfusion elicits an immune response that lacks a microbial constituent yet poses a potentially lethal threat to the host. In this sterile setting, the immune system is alarmed by endogenous danger signals that are release by stressed and dying liver cells. The detection of these immunogenic messengers by sentinel leukocyte populations constitutes the proximal trigger for a self-perpetuating cycle of inflammation, in which consecutive waves of cytokines and chemokines orchestrate the influx of various leukocyte subsets that ultimately confer tissue destruction. This review focuses on the temporal organization of sterile hepatic inflammation, using surgery-induced trauma as a template disease state. (C) 2012 Elsevier Ltd. All rights reserved

U2 - https://doi.org/10.1016/j.cytogfr.2012.04.006

DO - https://doi.org/10.1016/j.cytogfr.2012.04.006

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JF - Cytokine & Growth Factor Reviews

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