TY - JOUR
T1 - The STHLM3-model, Risk-based Prostate Cancer Testing Identifies Men at High Risk Without Inducing Negative Psychosocial Effects
AU - Koitsalu, Marie
AU - Eklund, Martin
AU - Adolfsson, Jan
AU - Sprangers, Mirjam A. G.
AU - Grönberg, Henrik
AU - Brandberg, Yvonne
N1 - Funding Information: Funding/Support and role of the sponsor: This work was supported by the Cancer Risk Prediction Center (CRisP), a Linneus Centre (contract ID 70867901) financed by the Swedish Research Council (Vetenskapsrådet) ; and by the Swedish Cancer Society (Cancerfonden) . The funders had no role in study design, data collection and analysis, preparation of the manuscript, or decision to publish the manuscript. Publisher Copyright: © 2020 The Author(s) Copyright: Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/2/1
Y1 - 2021/2/1
N2 - Background: The new STHLM3 test, combining protein markers, genetic markers, and clinical data to assess a man's prostate cancer (PCa) risk, has been investigated in Sweden within the frame of the STHLM3 trial. Objective: To assess whether the STHLM3 test influences men's worry level, PCa knowledge, attitude, and health-related quality of life (HRQoL). Design, setting, and participants: Invitations with login to the web survey were mailed to 10 000 men, 50–69 yr of age, who were eligible for the STHLM3 trial. The survey was sent 3 mo before invitation to the STHLM3 trial (baseline) and 5 mo after STHLM3 (follow-up). At baseline, the men were unaware of the upcoming invitation to STHLM3. The survey covered the following: PCa-specific worry and perceived vulnerability, knowledge about PCa, attitude toward PCa testing and health behavior, and HRQoL Outcome measurements and statistical analysis: Survey scores were compared between baseline and follow-up by using the nonparametric Wilcoxon-signed rank tests for paired samples. Analysis of covariance was performed for PCa risk group comparisons. Results and limitations: A total of 994 men (10%) responded to our survey at baseline and follow-up, and were assessed as follows: low risk: 421 men; intermediate risk: 421 men; and high risk:152, of whom 59 were diagnosed with PCa after further investigation. In men assessed as having low and intermediate risk, level of worrying decreased at follow-up (p < 0.001), whereas no changes were observed in men at high risk. Moreover, no HRQoL changes were observed over time. The low response rate is the main limitation. Conclusions: We found that the STHLM3 model, a risk-based PCa test, showed no negative impact on the well-being of men. Patient summary: Since our results suggest that the risk-based screening as used in STHLM3 did not induce negative psychological effects on the participants, we can recommend this risk-based approach for population-based prostate cancer screening.
AB - Background: The new STHLM3 test, combining protein markers, genetic markers, and clinical data to assess a man's prostate cancer (PCa) risk, has been investigated in Sweden within the frame of the STHLM3 trial. Objective: To assess whether the STHLM3 test influences men's worry level, PCa knowledge, attitude, and health-related quality of life (HRQoL). Design, setting, and participants: Invitations with login to the web survey were mailed to 10 000 men, 50–69 yr of age, who were eligible for the STHLM3 trial. The survey was sent 3 mo before invitation to the STHLM3 trial (baseline) and 5 mo after STHLM3 (follow-up). At baseline, the men were unaware of the upcoming invitation to STHLM3. The survey covered the following: PCa-specific worry and perceived vulnerability, knowledge about PCa, attitude toward PCa testing and health behavior, and HRQoL Outcome measurements and statistical analysis: Survey scores were compared between baseline and follow-up by using the nonparametric Wilcoxon-signed rank tests for paired samples. Analysis of covariance was performed for PCa risk group comparisons. Results and limitations: A total of 994 men (10%) responded to our survey at baseline and follow-up, and were assessed as follows: low risk: 421 men; intermediate risk: 421 men; and high risk:152, of whom 59 were diagnosed with PCa after further investigation. In men assessed as having low and intermediate risk, level of worrying decreased at follow-up (p < 0.001), whereas no changes were observed in men at high risk. Moreover, no HRQoL changes were observed over time. The low response rate is the main limitation. Conclusions: We found that the STHLM3 model, a risk-based PCa test, showed no negative impact on the well-being of men. Patient summary: Since our results suggest that the risk-based screening as used in STHLM3 did not induce negative psychological effects on the participants, we can recommend this risk-based approach for population-based prostate cancer screening.
KW - Health behavior
KW - Prostatic neoplasms
KW - Risk-based screening
KW - Worry
UR - http://www.scopus.com/inward/record.url?scp=85099176295&partnerID=8YFLogxK
U2 - https://doi.org/10.1016/j.euros.2020.12.010
DO - https://doi.org/10.1016/j.euros.2020.12.010
M3 - Article
C2 - 34337495
SN - 2666-1691
VL - 24
SP - 43
EP - 51
JO - European urology open science
JF - European urology open science
ER -