TY - JOUR
T1 - The story so far: Helicobacter pylori and gastric autoimmunity
AU - Bergman, Mathijs P.
AU - Vandenbroucke-Grauls, Christina M. J. E.
AU - Appelmelk, Ben J.
AU - D'Elios, Mario M.
AU - Amedei, Amedeo
AU - Azzurri, Annalisa
AU - Benagiano, Marisa
AU - del Prete, Gianfranco
PY - 2005
Y1 - 2005
N2 - The gastric mucosal pathogen Helicobacter pylori induces autoantibodies directed against the gastric proton pump H+,K+-ATPase in 20-30% of infected patients. The presence of these autoantibodies is associated with severity of gastritis, increased atrophy, and apoptosis in the corpus mucosa, and patients with these autoantibodies infected with H. pylori display histopathological and clinical features that are similar to those of autoimmune gastritis (AIG). This review will focus on the T helper cell responses, cytokines, and adhesion molecules involved in corpus mucosal atrophy in chronic H. pylori gastritis and in AIG, and the role of H. pylori in the onset of AIG
AB - The gastric mucosal pathogen Helicobacter pylori induces autoantibodies directed against the gastric proton pump H+,K+-ATPase in 20-30% of infected patients. The presence of these autoantibodies is associated with severity of gastritis, increased atrophy, and apoptosis in the corpus mucosa, and patients with these autoantibodies infected with H. pylori display histopathological and clinical features that are similar to those of autoimmune gastritis (AIG). This review will focus on the T helper cell responses, cytokines, and adhesion molecules involved in corpus mucosal atrophy in chronic H. pylori gastritis and in AIG, and the role of H. pylori in the onset of AIG
U2 - https://doi.org/10.1080/08830180590884648
DO - https://doi.org/10.1080/08830180590884648
M3 - Review article
C2 - 15763990
SN - 0883-0185
VL - 24
SP - 63
EP - 91
JO - International Reviews of Immunology
JF - International Reviews of Immunology
IS - 1-2
ER -
