TY - JOUR
T1 - The T-13910C polymorphism in the lactase phlorizin hydrolase gene is associated with differences in serum calcium levels and calcium intake
AU - Koek, W.
AU - van Meurs, J.
AU - van der Eerden, B.
AU - Rivadeneira, F.
AU - Zillikens, M.
AU - Hofman, A.
AU - Obermayer-Pietsch, B.
AU - Lips, P.T.A.M.
AU - Pols, H.
AU - Uitterlinden, A.
AU - van Leeuwen, J.
PY - 2010
Y1 - 2010
N2 - The C-variant of a T-13910C polymorphism (rs4988235; NT-022135.15:g. 25316568G>A) upstream of the lactase phlorizin hydrolase (LPH) gene causes lactose intolerance. Association studies with differences in bone parameters and fracture risk have been inconclusive. The objective of this study was to examine the association of LPH rs4988235 with body height and bone parameters and calcium homeostasis in two elderly populations of Dutch Caucasians and assess interaction with vitamin D receptor (VDR) polymorphisms. Genotyping of LPH and VDR polymorphisms was performed in 6367 individuals from the Rotterdam Study and 844 from the Longitudinal Aging Study Amsterdam (LASA). Associations with age, height, weight, bone mineral density (BMD), skeletal morphometric parameters and serum vitamin D and calcium levels, and dietary calcium intake were assessed using ANOVA or analysis of covariance, and allele dose effect was assessed using linear regression analysis. Fracture risk was analyzed using Cox's proportional hazard regression analysis. Associations with body height (p=2.7 x 10
AB - The C-variant of a T-13910C polymorphism (rs4988235; NT-022135.15:g. 25316568G>A) upstream of the lactase phlorizin hydrolase (LPH) gene causes lactose intolerance. Association studies with differences in bone parameters and fracture risk have been inconclusive. The objective of this study was to examine the association of LPH rs4988235 with body height and bone parameters and calcium homeostasis in two elderly populations of Dutch Caucasians and assess interaction with vitamin D receptor (VDR) polymorphisms. Genotyping of LPH and VDR polymorphisms was performed in 6367 individuals from the Rotterdam Study and 844 from the Longitudinal Aging Study Amsterdam (LASA). Associations with age, height, weight, bone mineral density (BMD), skeletal morphometric parameters and serum vitamin D and calcium levels, and dietary calcium intake were assessed using ANOVA or analysis of covariance, and allele dose effect was assessed using linear regression analysis. Fracture risk was analyzed using Cox's proportional hazard regression analysis. Associations with body height (p=2.7 x 10
U2 - https://doi.org/10.1002/jbmr.83
DO - https://doi.org/10.1002/jbmr.83
M3 - Article
C2 - 20225268
SN - 0884-0431
VL - 25
SP - 1980
EP - 1987
JO - Journal of bone and mineral research
JF - Journal of bone and mineral research
IS - 9
ER -