The TNF family member APRIL promotes colorectal tumorigenesis

V. Lascano; L. F. Zabalegui; K. Cameron; M. Guadagnoli; M. Jansen; M. Burggraaf; M. Versloot; H. Rodermond; C. van der Loos; C. E. Carvalho-Pinto; H. Kalthoff; J. P. Medema; M. Hahne

doi:https://doi.org/10.1038/cdd.2012.68

The TNF family member APRIL promotes colorectal tumorigenesis

V. Lascano, L. F. Zabalegui, K. Cameron, M. Guadagnoli, M. Jansen, M. Burggraaf, M. Versloot, H. Rodermond, C. van der Loos, C. E. Carvalho-Pinto, H. Kalthoff, J. P. Medema, M. Hahne

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25 Citations (Scopus)

Abstract

The tumor necrosis factor (TNF) family member APRIL (A proliferation inducing ligand) is a disease promoter in B-cell malignancies. APRIL has also been associated with a wide range of solid malignancies, including colorectal cancer (CRC). As evidence for a supportive role of APRIL in solid tumor formation was still lacking, we studied the involvement of APRIL in CRC. We observed that ectopic APRIL expression exacerbates the number and size of adenomas in Apc(Min) mice and in a mouse model for colitis-associated colon carcinogenesis. Furthermore, knockdown of APRIL in primary spheroid cultures of colon cancer cells and both mouse and human CRC cell lines reduced tumor clonogenicity and in vivo outgrowth. Taken together, our data therefore indicate that both tumor-derived APRIL and APRIL produced by non-tumor cells is supportive in colorectal tumorigenesis. Cell Death and Differentiation (2012) 19, 1826-1835; doi:10.1038/cdd.2012.68; published online 15 June 2012

Original language	English
Pages (from-to)	1826-1835
Journal	Cell death and differentiation
Volume	19
Issue number	11
DOIs	https://doi.org/10.1038/cdd.2012.68
Publication status	Published - 2012

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https://doi.org/10.1038/cdd.2012.68

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@article{6b82f465aeca4cd5b09108e5177aa282,

title = "The TNF family member APRIL promotes colorectal tumorigenesis",

abstract = "The tumor necrosis factor (TNF) family member APRIL (A proliferation inducing ligand) is a disease promoter in B-cell malignancies. APRIL has also been associated with a wide range of solid malignancies, including colorectal cancer (CRC). As evidence for a supportive role of APRIL in solid tumor formation was still lacking, we studied the involvement of APRIL in CRC. We observed that ectopic APRIL expression exacerbates the number and size of adenomas in Apc(Min) mice and in a mouse model for colitis-associated colon carcinogenesis. Furthermore, knockdown of APRIL in primary spheroid cultures of colon cancer cells and both mouse and human CRC cell lines reduced tumor clonogenicity and in vivo outgrowth. Taken together, our data therefore indicate that both tumor-derived APRIL and APRIL produced by non-tumor cells is supportive in colorectal tumorigenesis. Cell Death and Differentiation (2012) 19, 1826-1835; doi:10.1038/cdd.2012.68; published online 15 June 2012",

author = "V. Lascano and Zabalegui, {L. F.} and K. Cameron and M. Guadagnoli and M. Jansen and M. Burggraaf and M. Versloot and H. Rodermond and {van der Loos}, C. and Carvalho-Pinto, {C. E.} and H. Kalthoff and Medema, {J. P.} and M. Hahne",

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doi = "https://doi.org/10.1038/cdd.2012.68",

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T1 - The TNF family member APRIL promotes colorectal tumorigenesis

AU - Lascano, V.

AU - Zabalegui, L. F.

AU - Cameron, K.

AU - Guadagnoli, M.

AU - Jansen, M.

AU - Burggraaf, M.

AU - Versloot, M.

AU - Rodermond, H.

AU - van der Loos, C.

AU - Carvalho-Pinto, C. E.

AU - Kalthoff, H.

AU - Medema, J. P.

AU - Hahne, M.

PY - 2012

Y1 - 2012

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AB - The tumor necrosis factor (TNF) family member APRIL (A proliferation inducing ligand) is a disease promoter in B-cell malignancies. APRIL has also been associated with a wide range of solid malignancies, including colorectal cancer (CRC). As evidence for a supportive role of APRIL in solid tumor formation was still lacking, we studied the involvement of APRIL in CRC. We observed that ectopic APRIL expression exacerbates the number and size of adenomas in Apc(Min) mice and in a mouse model for colitis-associated colon carcinogenesis. Furthermore, knockdown of APRIL in primary spheroid cultures of colon cancer cells and both mouse and human CRC cell lines reduced tumor clonogenicity and in vivo outgrowth. Taken together, our data therefore indicate that both tumor-derived APRIL and APRIL produced by non-tumor cells is supportive in colorectal tumorigenesis. Cell Death and Differentiation (2012) 19, 1826-1835; doi:10.1038/cdd.2012.68; published online 15 June 2012

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