The transmission of Mycobacterium tuberculosis in high burden settings

Tom A. Yates; Palwasha Y. Khan; Gwenan M. Knight; Jonathon G. Taylor; Timothy D. McHugh; Marc Lipman; Richard G. White; Ted Cohen; Frank G. Cobelens; Robin Wood; David A. J. Moore; Ibrahim Abubakar

doi:https://doi.org/10.1016/S1473-3099(15)00499-5

The transmission of Mycobacterium tuberculosis in high burden settings

Tom A. Yates, Palwasha Y. Khan, Gwenan M. Knight, Jonathon G. Taylor, Timothy D. McHugh, Marc Lipman, Richard G. White, Ted Cohen, Frank G. Cobelens, Robin Wood, David A. J. Moore, Ibrahim Abubakar

Research output: Contribution to journal › Review article › Academic › peer-review

134 Citations (Scopus)

Abstract

Unacceptable levels of Mycobacterium tuberculosis transmission are noted in high burden settings and a renewed focus on reducing person-to-person transmission in these communities is needed. We review recent developments in the understanding of airborne transmission. We outline approaches to measure transmission in populations and trials and describe the Wells-Riley equation, which is used to estimate transmission risk in indoor spaces. Present research priorities include the identification of effective strategies for tuberculosis infection control, improved understanding of where transmission occurs and the transmissibility of drug-resistant strains, and estimates of the effect of HIV and antiretroviral therapy on transmission dynamics. When research is planned and interventions are designed to interrupt transmission, resource constraints that are common in high burden settings-including shortages of health-care workers-must be considered

Original language	English
Pages (from-to)	227-238
Journal	Lancet infectious diseases
Volume	16
Issue number	2
DOIs	https://doi.org/10.1016/S1473-3099(15)00499-5
Publication status	Published - 2016

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https://doi.org/10.1016/S1473-3099(15)00499-5

Cite this

@article{16e7cdebd6d64e3c98b2485f407f72fb,

title = "The transmission of Mycobacterium tuberculosis in high burden settings",

abstract = "Unacceptable levels of Mycobacterium tuberculosis transmission are noted in high burden settings and a renewed focus on reducing person-to-person transmission in these communities is needed. We review recent developments in the understanding of airborne transmission. We outline approaches to measure transmission in populations and trials and describe the Wells-Riley equation, which is used to estimate transmission risk in indoor spaces. Present research priorities include the identification of effective strategies for tuberculosis infection control, improved understanding of where transmission occurs and the transmissibility of drug-resistant strains, and estimates of the effect of HIV and antiretroviral therapy on transmission dynamics. When research is planned and interventions are designed to interrupt transmission, resource constraints that are common in high burden settings-including shortages of health-care workers-must be considered",

author = "Yates, {Tom A.} and Khan, {Palwasha Y.} and Knight, {Gwenan M.} and Taylor, {Jonathon G.} and McHugh, {Timothy D.} and Marc Lipman and White, {Richard G.} and Ted Cohen and Cobelens, {Frank G.} and Robin Wood and Moore, {David A. J.} and Ibrahim Abubakar",

year = "2016",

doi = "https://doi.org/10.1016/S1473-3099(15)00499-5",

language = "English",

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TY - JOUR

T1 - The transmission of Mycobacterium tuberculosis in high burden settings

AU - Yates, Tom A.

AU - Khan, Palwasha Y.

AU - Knight, Gwenan M.

AU - Taylor, Jonathon G.

AU - McHugh, Timothy D.

AU - Lipman, Marc

AU - White, Richard G.

AU - Cohen, Ted

AU - Cobelens, Frank G.

AU - Wood, Robin

AU - Moore, David A. J.

AU - Abubakar, Ibrahim

PY - 2016

Y1 - 2016

N2 - Unacceptable levels of Mycobacterium tuberculosis transmission are noted in high burden settings and a renewed focus on reducing person-to-person transmission in these communities is needed. We review recent developments in the understanding of airborne transmission. We outline approaches to measure transmission in populations and trials and describe the Wells-Riley equation, which is used to estimate transmission risk in indoor spaces. Present research priorities include the identification of effective strategies for tuberculosis infection control, improved understanding of where transmission occurs and the transmissibility of drug-resistant strains, and estimates of the effect of HIV and antiretroviral therapy on transmission dynamics. When research is planned and interventions are designed to interrupt transmission, resource constraints that are common in high burden settings-including shortages of health-care workers-must be considered

AB - Unacceptable levels of Mycobacterium tuberculosis transmission are noted in high burden settings and a renewed focus on reducing person-to-person transmission in these communities is needed. We review recent developments in the understanding of airborne transmission. We outline approaches to measure transmission in populations and trials and describe the Wells-Riley equation, which is used to estimate transmission risk in indoor spaces. Present research priorities include the identification of effective strategies for tuberculosis infection control, improved understanding of where transmission occurs and the transmissibility of drug-resistant strains, and estimates of the effect of HIV and antiretroviral therapy on transmission dynamics. When research is planned and interventions are designed to interrupt transmission, resource constraints that are common in high burden settings-including shortages of health-care workers-must be considered

U2 - https://doi.org/10.1016/S1473-3099(15)00499-5

DO - https://doi.org/10.1016/S1473-3099(15)00499-5

M3 - Review article

C2 - 26867464

SN - 1473-3099

VL - 16

SP - 227

EP - 238

JO - Lancet infectious diseases

JF - Lancet infectious diseases

IS - 2

ER -