The uncertain glory of APRIL

J. P. Medema; L. Planelles-Carazo; G. Hardenberg; M. Hahne

doi:https://doi.org/10.1038/sj.cdd.4401291

The uncertain glory of APRIL

J. P. Medema, L. Planelles-Carazo, G. Hardenberg, M. Hahne

Research output: Contribution to journal › Review article › Academic › peer-review

44 Citations (Scopus)

Abstract

The tumour necrosis factor (TNF) family is intimately connected to the regulation of cellular pathways. A PRoliferation-Inducing Ligand (APRIL) is a rather new member of that family, named for its capacity to stimulate the proliferation of tumour cells in vitro. Subsequent publications also called this ligand TRDL-1 or TALL-2, respectively. APRIL and B-lymphocyte stimulator (BLyS; also termed BAFF, TALL-1, THANK, zTNF4) form a new subfamily of TNF-like ligands that are expressed in haematopoietic cells. Both ligands can bind the two members of the TNF receptor family, namely the transmembrane activator and calcium modulator cyclophilin ligand interactor (TACI), as well as B-cell maturation antigen (BCMA). BLyS has recently been the subject of several reviews (for an extensive review, see Mackay et al.). The present review will thus focus on APRIL, and discuss BLyS only briefly for the sake of clarity

Original language	English
Pages (from-to)	1121-1125
Journal	Cell death and differentiation
Volume	10
Issue number	10
DOIs	https://doi.org/10.1038/sj.cdd.4401291
Publication status	Published - 2003

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https://doi.org/10.1038/sj.cdd.4401291

Cite this

@article{8f106c96a5514ec085f4c8c638e92dee,

title = "The uncertain glory of APRIL",

abstract = "The tumour necrosis factor (TNF) family is intimately connected to the regulation of cellular pathways. A PRoliferation-Inducing Ligand (APRIL) is a rather new member of that family, named for its capacity to stimulate the proliferation of tumour cells in vitro. Subsequent publications also called this ligand TRDL-1 or TALL-2, respectively. APRIL and B-lymphocyte stimulator (BLyS; also termed BAFF, TALL-1, THANK, zTNF4) form a new subfamily of TNF-like ligands that are expressed in haematopoietic cells. Both ligands can bind the two members of the TNF receptor family, namely the transmembrane activator and calcium modulator cyclophilin ligand interactor (TACI), as well as B-cell maturation antigen (BCMA). BLyS has recently been the subject of several reviews (for an extensive review, see Mackay et al.). The present review will thus focus on APRIL, and discuss BLyS only briefly for the sake of clarity",

author = "Medema, {J. P.} and L. Planelles-Carazo and G. Hardenberg and M. Hahne",

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TY - JOUR

T1 - The uncertain glory of APRIL

AU - Medema, J. P.

AU - Planelles-Carazo, L.

AU - Hardenberg, G.

AU - Hahne, M.

PY - 2003

Y1 - 2003

N2 - The tumour necrosis factor (TNF) family is intimately connected to the regulation of cellular pathways. A PRoliferation-Inducing Ligand (APRIL) is a rather new member of that family, named for its capacity to stimulate the proliferation of tumour cells in vitro. Subsequent publications also called this ligand TRDL-1 or TALL-2, respectively. APRIL and B-lymphocyte stimulator (BLyS; also termed BAFF, TALL-1, THANK, zTNF4) form a new subfamily of TNF-like ligands that are expressed in haematopoietic cells. Both ligands can bind the two members of the TNF receptor family, namely the transmembrane activator and calcium modulator cyclophilin ligand interactor (TACI), as well as B-cell maturation antigen (BCMA). BLyS has recently been the subject of several reviews (for an extensive review, see Mackay et al.). The present review will thus focus on APRIL, and discuss BLyS only briefly for the sake of clarity

AB - The tumour necrosis factor (TNF) family is intimately connected to the regulation of cellular pathways. A PRoliferation-Inducing Ligand (APRIL) is a rather new member of that family, named for its capacity to stimulate the proliferation of tumour cells in vitro. Subsequent publications also called this ligand TRDL-1 or TALL-2, respectively. APRIL and B-lymphocyte stimulator (BLyS; also termed BAFF, TALL-1, THANK, zTNF4) form a new subfamily of TNF-like ligands that are expressed in haematopoietic cells. Both ligands can bind the two members of the TNF receptor family, namely the transmembrane activator and calcium modulator cyclophilin ligand interactor (TACI), as well as B-cell maturation antigen (BCMA). BLyS has recently been the subject of several reviews (for an extensive review, see Mackay et al.). The present review will thus focus on APRIL, and discuss BLyS only briefly for the sake of clarity

U2 - https://doi.org/10.1038/sj.cdd.4401291

DO - https://doi.org/10.1038/sj.cdd.4401291

M3 - Review article

C2 - 14502235

SN - 1350-9047

VL - 10

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EP - 1125

JO - Cell death and differentiation

JF - Cell death and differentiation

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