TY - JOUR
T1 - The UPHILL study
T2 - A nutrition and lifestyle intervention to improve quality of life for patients with pulmonary arterial hypertension
AU - Kwant, Chermaine T.
AU - de Man, Frances
AU - van der Horst, Frans A. L.
AU - Bogaard, Harm J.
AU - Vonk Noordegraaf, Anton
N1 - Funding Information: We gratefully thank Mary Nicolau from the Department of Public Health of the Amsterdam University Medical Centre for providing us information on interpreting data from the HELIUS food frequency questionnaire. We thank Daphne Kortekaas from Dapphdesign for designing the workbook and photographer Daisy von Dutch for the workbook pictures. This investigator‐sponsored study was financially supported by Janssen‐Cilag B. V. Publisher Copyright: © 2023 The Authors. Pulmonary Circulation published by John Wiley & Sons Ltd on behalf of Pulmonary Vascular Research Institute.
PY - 2023/4/1
Y1 - 2023/4/1
N2 - The aim of the UPHILL study (a nutrition and lifestyle intervention in patients with pulmonary arterial hypertension [PAH]: effect on quality of life [QoL]), was to determine the effect of innovative nutritional interventions on adjustments in nutritional intake and QoL. In this study a group of prevalent PAH patients at a single center in Amsterdam (the Netherlands) was informed about healthy nutrition using a newly designed video e-learning. They were subsequently instructed to follow a healthy diet during dietary intervention. Nutritional intake was assessed using a food frequency questionnaire (HELIUS) and QoL by the short-form (SF)-36 questionnaire. Nutritional parameters were determined in blood samples. Seventeen patients stable under treatment, who had been diagnosed with PAH 7.0 [3.0−14.0] years before, started and completed the intervention (2 males, 15 females; 45.35 ± 13.57 years). Since all patients in the intervention group made behavioral changes in nutritional intake, during study and follow-up, nutritional and lifestyle adaptations persisted. Despite the fact that patients had already high mean scores at baseline for both mental (74.10 [60.51−84.25]) and physical QoL (66.46 [50.21−73.84]), scores improved further during e-learning. Furthermore, patients who realized most nutritional adaptations, had the best improvement in QoL. This pilot study showed that e-learning modules on nutrition provide an unique opportunity to change nutritional intake in PAH patients and by that improve QoL.
AB - The aim of the UPHILL study (a nutrition and lifestyle intervention in patients with pulmonary arterial hypertension [PAH]: effect on quality of life [QoL]), was to determine the effect of innovative nutritional interventions on adjustments in nutritional intake and QoL. In this study a group of prevalent PAH patients at a single center in Amsterdam (the Netherlands) was informed about healthy nutrition using a newly designed video e-learning. They were subsequently instructed to follow a healthy diet during dietary intervention. Nutritional intake was assessed using a food frequency questionnaire (HELIUS) and QoL by the short-form (SF)-36 questionnaire. Nutritional parameters were determined in blood samples. Seventeen patients stable under treatment, who had been diagnosed with PAH 7.0 [3.0−14.0] years before, started and completed the intervention (2 males, 15 females; 45.35 ± 13.57 years). Since all patients in the intervention group made behavioral changes in nutritional intake, during study and follow-up, nutritional and lifestyle adaptations persisted. Despite the fact that patients had already high mean scores at baseline for both mental (74.10 [60.51−84.25]) and physical QoL (66.46 [50.21−73.84]), scores improved further during e-learning. Furthermore, patients who realized most nutritional adaptations, had the best improvement in QoL. This pilot study showed that e-learning modules on nutrition provide an unique opportunity to change nutritional intake in PAH patients and by that improve QoL.
KW - diet
KW - e-learning
KW - lifestyle
KW - nutrition
KW - pulmonary hypertension
UR - http://www.scopus.com/inward/record.url?scp=85162098797&partnerID=8YFLogxK
U2 - https://doi.org/10.1002/pul2.12243
DO - https://doi.org/10.1002/pul2.12243
M3 - Article
C2 - 37252180
SN - 2045-8932
VL - 13
JO - PULMONARY CIRCULATION
JF - PULMONARY CIRCULATION
IS - 2
M1 - e12243
ER -