The use of allograft tendons in primary ACL reconstruction

Christophe Hulet, Bertrand Sonnery-Cottet, Ciara Stevenson, Kristian Samuelsson, Lior Laver, Urszula Zdanowicz, Sjoerd Stufkens, Jonathan Curado, Peter Verdonk, Tim Spalding

Research output: Contribution to journalReview articleAcademicpeer-review

51 Citations (Scopus)


Purpose: Graft choice in primary anterior cruciate ligament (ACL) reconstruction remains controversial. The use of allograft has risen exponentially in recent years with the attraction of absent donor site morbidity, reduced surgical time and reliable graft size. However, the published evidence examining their clinical effectiveness over autograft tendons has been unclear. The aim of this paper is to provide a current review of the clinical evidence available to help guide surgeons through the decision-making process for the use of allografts in primary ACL reconstruction. Methods: The literature in relation to allograft healing, storage, sterilisation, differences in surgical technique and rehabilitation have been reviewed in addition to recent comparative studies and all clinical systematic reviews and meta-analyses. Results: Early reviews have indicated a higher risk of failure with allografts due to association with irradiation for sterilisation and where rehabilitation programs and post-operative loading may ignore the slower incorporation of allografts. More recent analysis indicates a similar low failure rate for allograft and autograft methods of reconstruction when using non-irradiated allografts that have not undergone chemically processing and where rehabilitation has been slower. However, inferior outcomes with allografts have been reported in young (< 25 years) highly active patients, and also when irradiated or chemically processed grafts are used. Conclusion: When considering use of allografts in primary ACL reconstruction, use of irradiation, chemical processing and rehabilitation programs suited to autograft are important negative factors. Allografts, when used for primary ACL reconstruction, should be fresh frozen and non-irradiated. Quantification of the risk of use of allograft in the young requires further evaluation. Levels of evidence: III.
Original languageEnglish
Pages (from-to)1754-1770
Number of pages17
JournalKnee surgery, sports traumatology, arthroscopy
Issue number6
Publication statusPublished - 1 Jun 2019

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