TY - CHAP
T1 - THE USE OF GONADOTROPIN-RELEASING HORMONE AGONISTS AND THE EFFICIENCY OF IN VITRO FERTILIZATION
AU - Patrizio, Pasquale
AU - Ghazal, Sanaz
AU - Huirne, Judith A. F.
AU - Schats, Roel
PY - 2023/1/1
Y1 - 2023/1/1
N2 - Gonadotropin-releasing hormone (GnRH) is the primary hypothalamic regulator of reproductive function. The chemical structure of this compound was discovered in 1971 by a group of scientists in Andrew Schally’s laboratory in New Orleans after they derived a small amount of GnRH from porcine hypothalami [1, 2]. Roger Guillemin then characterized and independently synthesized the hormone, and he and Schally received the Nobel Prize for their achievements. GnRH is a decapeptide that is synthesized as part of a much larger precursor peptide, the GnRH-associated peptide. This peptide is composed of a sequence of 56 amino acids. The availability of the synthetic hormone for dynamic endocrine testing and receptor studies created new insights into the physiological role of GnRH in the hypothalamic-pituitary-gonadal axis [3].
AB - Gonadotropin-releasing hormone (GnRH) is the primary hypothalamic regulator of reproductive function. The chemical structure of this compound was discovered in 1971 by a group of scientists in Andrew Schally’s laboratory in New Orleans after they derived a small amount of GnRH from porcine hypothalami [1, 2]. Roger Guillemin then characterized and independently synthesized the hormone, and he and Schally received the Nobel Prize for their achievements. GnRH is a decapeptide that is synthesized as part of a much larger precursor peptide, the GnRH-associated peptide. This peptide is composed of a sequence of 56 amino acids. The availability of the synthetic hormone for dynamic endocrine testing and receptor studies created new insights into the physiological role of GnRH in the hypothalamic-pituitary-gonadal axis [3].
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85183254143&origin=inward
U2 - 10.1201/9781003268611-42
DO - 10.1201/9781003268611-42
M3 - Chapter
SN - 9781032214801
VL - 2
T3 - Textbook of Assisted Reproductive Techniques: Volume 2: Clinical Perspectives, Sixth Edition
SP - 463
EP - 471
BT - Textbook of Assisted Reproductive Techniques: Volume 2: Clinical Perspectives, Sixth Edition
PB - CRC Press
ER -