The use of host cell DNA methylation analysis in the detection and management of women with advanced cervical intraepithelial neoplasia: a review: a review

W. W. Kremer, R. D. M. Steenbergen, D. A. M. Heideman, G. G. Kenter, C. J. L. M. Meijer

Research output: Contribution to journalReview articleAcademicpeer-review

34 Citations (Scopus)


This paper briefly reviews the role of hypermethylation of host cell genes in cervical carcinogenesis and discusses potential clinical applications of methylation analysis in the management of high-risk HPV (hrHPV) -positive women. We argue that methylation assays can be used: 1. for primary triage of hrHPV-positive women to detect cervical cancer and advanced cervical intraepithelial neoplasia (CIN); 2. as secondary triage for women with minor cytological abnormalities to identify those with the highest risk of CIN3 or worse; 3. as exit test for women leaving the screening programme to identify cervical cancer and advanced CIN; and 4. to support management of CIN. Tweetable abstract: This paper discusses potential clinical applications of DNA methylation analysis in the management of women with a high-risk HPV infection.

Original languageEnglish
Pages (from-to)504-514
Number of pages11
JournalBJOG: An International Journal of Obstetrics and Gynaecology
Issue number3
Early online date3 Jul 2020
Publication statusPublished - Feb 2021


  • DNA methylation
  • cervical cancer screening
  • cervical intraepithelial neoplasia
  • human papillomavirus

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