Abstract
This paper briefly reviews the role of hypermethylation of host cell genes in cervical carcinogenesis and discusses potential clinical applications of methylation analysis in the management of high-risk HPV (hrHPV) -positive women. We argue that methylation assays can be used: 1. for primary triage of hrHPV-positive women to detect cervical cancer and advanced cervical intraepithelial neoplasia (CIN); 2. as secondary triage for women with minor cytological abnormalities to identify those with the highest risk of CIN3 or worse; 3. as exit test for women leaving the screening programme to identify cervical cancer and advanced CIN; and 4. to support management of CIN. Tweetable abstract: This paper discusses potential clinical applications of DNA methylation analysis in the management of women with a high-risk HPV infection.
| Original language | English |
|---|---|
| Pages (from-to) | 504-514 |
| Number of pages | 11 |
| Journal | BJOG: An International Journal of Obstetrics and Gynaecology |
| Volume | 128 |
| Issue number | 3 |
| Early online date | 3 Jul 2020 |
| DOIs | |
| Publication status | Published - Feb 2021 |
Keywords
- DNA methylation
- cervical cancer screening
- cervical intraepithelial neoplasia
- human papillomavirus