TY - JOUR
T1 - The value of regular follow-up of oral leukoplakia for early detection of malignant transformation
AU - Evren, Ilkay
AU - Najim, Ahmad M.
AU - Poell, Jos B.
AU - Brouns, Elisabeth R.
AU - Wils, Leon J.
AU - Peferoen, Laura A. N.
AU - Brakenhoff, Ruud H.
AU - Bloemena, Elisabeth
AU - van der Meij, Erik H.
AU - de Visscher, Jan G. A. M.
N1 - Publisher Copyright: © 2023 The Authors. Oral Diseases published by Wiley Periodicals LLC.
PY - 2023
Y1 - 2023
N2 - Objectives: Evaluate whether regular follow-up of oral leukoplakia (OL) resulted in early detection of malignant transformation (MT). Method: Two hundred and twenty-two consecutive patients with OL (147 females, 75 males); median follow-up period of 64 months (range: 12–300). Three groups were distinguished: group A (n = 92) follow-up at the hospital; group B (n = 84) follow-up by their dentist; group C (n = 46) lost to follow-up. Results: OLs in group B compared to group A, were smaller in size (<2 cm; p < 0.001), showed more hyperkeratosis (p < 0.001) and less moderate/severe dysplasia (p < 0.001). MT occurred in 45 (20%) patients: 32 (35%) in group A, five (6%) in group B and eight (17%) in group C. There was no significant difference in clinical tumour size between group A (median: 15 mm, range: 1–40) and group B (median: 10 mm, range: 3–25; p = 0.496). Tumour size was smaller for patients in groups A and B (median: 10 mm, range 1–40) compared to group C (median: 33 mm, range: 3–100; p = 0.003). There was a positive correlation between tumour size and interval between the last visit in all patients (p = 0.022). Conclusion: Regular follow-up of OL resulted in early detection of MT. If properly selected, follow-up of OL performed by the dentist seems feasible.
AB - Objectives: Evaluate whether regular follow-up of oral leukoplakia (OL) resulted in early detection of malignant transformation (MT). Method: Two hundred and twenty-two consecutive patients with OL (147 females, 75 males); median follow-up period of 64 months (range: 12–300). Three groups were distinguished: group A (n = 92) follow-up at the hospital; group B (n = 84) follow-up by their dentist; group C (n = 46) lost to follow-up. Results: OLs in group B compared to group A, were smaller in size (<2 cm; p < 0.001), showed more hyperkeratosis (p < 0.001) and less moderate/severe dysplasia (p < 0.001). MT occurred in 45 (20%) patients: 32 (35%) in group A, five (6%) in group B and eight (17%) in group C. There was no significant difference in clinical tumour size between group A (median: 15 mm, range: 1–40) and group B (median: 10 mm, range: 3–25; p = 0.496). Tumour size was smaller for patients in groups A and B (median: 10 mm, range 1–40) compared to group C (median: 33 mm, range: 3–100; p = 0.003). There was a positive correlation between tumour size and interval between the last visit in all patients (p = 0.022). Conclusion: Regular follow-up of OL resulted in early detection of MT. If properly selected, follow-up of OL performed by the dentist seems feasible.
KW - early detection of cancer
KW - oral cancer
KW - oral epithelial dysplasia
KW - oral leukoplakia
KW - oral potentially malignant disorder
KW - oral squamous cell carcinoma
UR - http://www.scopus.com/inward/record.url?scp=85176152844&partnerID=8YFLogxK
U2 - https://doi.org/10.1111/odi.14797
DO - https://doi.org/10.1111/odi.14797
M3 - Article
C2 - 37936517
SN - 1354-523X
JO - Oral diseases
JF - Oral diseases
ER -