TY - JOUR
T1 - The young Netherlands twin register (YNTR)
T2 - Longitudinal twin and family studies in over 70,000 children
AU - van Beijsterveldt, Catharina E. M.
AU - Groen-Blokhuis, Maria
AU - Hottenga, Jouke Jan
AU - Franić, Sanja
AU - Hudziak, James J.
AU - Lamb, Diane
AU - Huppertz, Charlotte
AU - de Zeeuw, Eveline
AU - Nivard, Michel
AU - Schutte, Nienke
AU - Swagerman, Suzanne
AU - Glasner, Tina
AU - van Fulpen, Michelle
AU - Brouwer, Cyrina
AU - Stroet, Therese
AU - Nowotny, Dustin
AU - Ehli, Erik A.
AU - Davies, Gareth E.
AU - Scheet, Paul
AU - Orlebeke, Jacob F.
AU - Kan, Kees-Jan
AU - Smit, Dirk
AU - Dolan, Conor V.
AU - Middeldorp, Christel M.
AU - de Geus, Eco J. C.
AU - Bartels, Meike
AU - Boomsma, Dorret I.
PY - 2013/2
Y1 - 2013/2
N2 - The Netherlands Twin Register (NTR) began in 1987 with data collection in twins and their families, including families with newborn twins and triplets. Twenty-five years later, the NTR has collected at least one survey for 70,784 children, born after 1985. For the majority of twins, longitudinal data collection has been done by age-specific surveys. Shortly after giving birth, mothers receive a first survey with items on pregnancy and birth. At age 2, a survey on growth and achievement of milestones is sent. At ages 3, 7, 9/10, and 12 parents and teachers receive a series of surveys that are targeted at the development of emotional and behavior problems. From age 14 years onward, adolescent twins and their siblings report on their behavior problems, health, and lifestyle. When the twins are 18 years and older, parents are also invited to take part in survey studies. In sub-groups of different ages, in-depth phenotyping was done for IQ, electroencephalography , MRI, growth, hormones, neuropsychological assessments, and cardiovascular measures. DNA and biological samples have also been collected and large numbers of twin pairs and parents have been genotyped for zygosity by either micro-satellites or sets of short nucleotide polymorphisms and repeat polymorphisms in candidate genes. Subject recruitment and data collection is still ongoing and the longitudinal database is growing. Data collection by record linkage in the Netherlands is beginning and we expect these combined longitudinal data to provide increased insights into the genetic etiology of development of mental and physical health in children and adolescents. Copyright © The Authors 2012.
AB - The Netherlands Twin Register (NTR) began in 1987 with data collection in twins and their families, including families with newborn twins and triplets. Twenty-five years later, the NTR has collected at least one survey for 70,784 children, born after 1985. For the majority of twins, longitudinal data collection has been done by age-specific surveys. Shortly after giving birth, mothers receive a first survey with items on pregnancy and birth. At age 2, a survey on growth and achievement of milestones is sent. At ages 3, 7, 9/10, and 12 parents and teachers receive a series of surveys that are targeted at the development of emotional and behavior problems. From age 14 years onward, adolescent twins and their siblings report on their behavior problems, health, and lifestyle. When the twins are 18 years and older, parents are also invited to take part in survey studies. In sub-groups of different ages, in-depth phenotyping was done for IQ, electroencephalography , MRI, growth, hormones, neuropsychological assessments, and cardiovascular measures. DNA and biological samples have also been collected and large numbers of twin pairs and parents have been genotyped for zygosity by either micro-satellites or sets of short nucleotide polymorphisms and repeat polymorphisms in candidate genes. Subject recruitment and data collection is still ongoing and the longitudinal database is growing. Data collection by record linkage in the Netherlands is beginning and we expect these combined longitudinal data to provide increased insights into the genetic etiology of development of mental and physical health in children and adolescents. Copyright © The Authors 2012.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84873937105&origin=inward
UR - https://www.ncbi.nlm.nih.gov/pubmed/23186620
U2 - https://doi.org/10.1017/thg.2012.118
DO - https://doi.org/10.1017/thg.2012.118
M3 - Article
C2 - 23186620
SN - 1832-4274
VL - 16
SP - 252
EP - 267
JO - Twin research and human genetics
JF - Twin research and human genetics
IS - 1
ER -