Therapeutic application of adipose derived stem cells in acute myocardial infarction: lessons from animal models

B.A. Naaijkens; A . van Dijk; O. Kamp; P.A.J. Krijnen; H.W.M. Niessen; L.J.M. Juffermans

doi:https://doi.org/10.1007/s12015-014-9502-7

Therapeutic application of adipose derived stem cells in acute myocardial infarction: lessons from animal models

B.A. Naaijkens, A . van Dijk, O. Kamp, P.A.J. Krijnen, H.W.M. Niessen, L.J.M. Juffermans

Research output: Contribution to journal › Review article › Academic › peer-review

24 Citations (Scopus)

Abstract

The majority of patients survive an acute myocardial infarction (AMI). Their outcome is negatively influenced by post-AMI events, such as loss of viable cardiomyocytes due to a post-AMI inflammatory response, eventually resulting in heart failure and/or death. Recent pre-clinical animal studies indicate that mesenchymal stem cells derived from adipose tissue (ASC) are new promising candidates that may facilitate cardiovascular regeneration in the infarcted myocardium. In this review we have compared all animal studies in which ASC were used as a therapy post-AMI and have focused on aspects that might be important for future successful clinical application of ASC.

Original language	English
Pages (from-to)	389-398
Number of pages	10
Journal	STEM CELL REVIEWS AND REPORTS
Volume	10
Issue number	3
DOIs	https://doi.org/10.1007/s12015-014-9502-7
Publication status	Published - Jun 2014

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https://doi.org/10.1007/s12015-014-9502-7

Cite this

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title = "Therapeutic application of adipose derived stem cells in acute myocardial infarction: lessons from animal models",

abstract = "The majority of patients survive an acute myocardial infarction (AMI). Their outcome is negatively influenced by post-AMI events, such as loss of viable cardiomyocytes due to a post-AMI inflammatory response, eventually resulting in heart failure and/or death. Recent pre-clinical animal studies indicate that mesenchymal stem cells derived from adipose tissue (ASC) are new promising candidates that may facilitate cardiovascular regeneration in the infarcted myocardium. In this review we have compared all animal studies in which ASC were used as a therapy post-AMI and have focused on aspects that might be important for future successful clinical application of ASC.",

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T2 - lessons from animal models

AU - Naaijkens, B.A.

AU - van Dijk, A .

AU - Kamp, O.

AU - Krijnen, P.A.J.

AU - Niessen, H.W.M.

AU - Juffermans, L.J.M.

PY - 2014/6

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N2 - The majority of patients survive an acute myocardial infarction (AMI). Their outcome is negatively influenced by post-AMI events, such as loss of viable cardiomyocytes due to a post-AMI inflammatory response, eventually resulting in heart failure and/or death. Recent pre-clinical animal studies indicate that mesenchymal stem cells derived from adipose tissue (ASC) are new promising candidates that may facilitate cardiovascular regeneration in the infarcted myocardium. In this review we have compared all animal studies in which ASC were used as a therapy post-AMI and have focused on aspects that might be important for future successful clinical application of ASC.

AB - The majority of patients survive an acute myocardial infarction (AMI). Their outcome is negatively influenced by post-AMI events, such as loss of viable cardiomyocytes due to a post-AMI inflammatory response, eventually resulting in heart failure and/or death. Recent pre-clinical animal studies indicate that mesenchymal stem cells derived from adipose tissue (ASC) are new promising candidates that may facilitate cardiovascular regeneration in the infarcted myocardium. In this review we have compared all animal studies in which ASC were used as a therapy post-AMI and have focused on aspects that might be important for future successful clinical application of ASC.

U2 - https://doi.org/10.1007/s12015-014-9502-7

DO - https://doi.org/10.1007/s12015-014-9502-7

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JF - STEM CELL REVIEWS AND REPORTS

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