Thrombophilia Mediates Lowering Cardiovascular Risk Factors in Women with a History of Preeclampsia

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Objective. Preeclampsia is associated with increased risk of cardiovascular disease. The aim of this pilot study was to assess whether the presence of thrombophilia results in a greater tendency to develop endothelial dysfunction and cardiovascular diseases. Methods. Ten women with thrombophilia were matched with 10 women without thrombophilia for a history of hypertensive disorders during pregnancy. Laboratory measurements: blood pressure, insulin sensitivity, and micro- and macrovascular function were determined. Results. Women with thrombophilia had significant lower total- and low-density cholesterol, were more insulin sensitive, and had better microvascular function. Conclusion. This study suggests that thrombophilia "mediates" in lowering of cardiovascular risk factors in women with a history of preeclampsia. © 2011 Informa Healthcare USA, Inc.
Original languageEnglish
Pages (from-to)421-432
JournalHypertension in pregnancy
Issue number4
Publication statusPublished - 2011

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