TY - CHAP
T1 - Thyroid and Cardiovascular Risk
AU - den Elzen, Wendy P. J.
AU - Mooijaart, Simon P.
AU - Ballieux, Bart E. P. B.
AU - Cappola, Anne R.
AU - Gussekloo, Jacobijn
PY - 2020/1/1
Y1 - 2020/1/1
N2 - Here we present data on the clinical effects of abnormalities in thyroid hormone levels on cardiovascular risk, focusing on the risks associated with subclinical thyroid dysfunction. Some observational studies and randomized clinical trials have suggested that subclinical hypothyroidism causes reversible alterations in surrogate markers of cardiovascular disease such as lipid levels and carotid intima media thickness. RCTs and meta-analyses to date have not shown effects of levothyroxine treatment for patients with subclinical hypothyroidism on clinical and cardiovascular outcomes, but were underpowered to detect effects on cardiac events and mortality. Observational data strongly support the treatment of subclinical hyperthyroidism to prevent atrial fibrillation and heart failure, but the degree to which the cardiovascular risk is reversible is unknown since prospective, randomized controlled trials of treatment of subclinical hyperthyroidism are not available.
AB - Here we present data on the clinical effects of abnormalities in thyroid hormone levels on cardiovascular risk, focusing on the risks associated with subclinical thyroid dysfunction. Some observational studies and randomized clinical trials have suggested that subclinical hypothyroidism causes reversible alterations in surrogate markers of cardiovascular disease such as lipid levels and carotid intima media thickness. RCTs and meta-analyses to date have not shown effects of levothyroxine treatment for patients with subclinical hypothyroidism on clinical and cardiovascular outcomes, but were underpowered to detect effects on cardiac events and mortality. Observational data strongly support the treatment of subclinical hyperthyroidism to prevent atrial fibrillation and heart failure, but the degree to which the cardiovascular risk is reversible is unknown since prospective, randomized controlled trials of treatment of subclinical hyperthyroidism are not available.
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85134866301&origin=inward
U2 - https://doi.org/10.1007/978-3-030-36871-5_16
DO - https://doi.org/10.1007/978-3-030-36871-5_16
M3 - Chapter
SN - 9783030368708
T3 - Thyroid and Heart: A Comprehensive Translational Essay, Second Edition
SP - 205
EP - 227
BT - Thyroid and Heart: A Comprehensive Translational Essay, Second Edition
PB - Springer International Publishing
ER -