TY - JOUR
T1 - Thyrotropin Secretion Profiles Are Not Different in Men and Women
AU - Roelfsema, Ferdinand
AU - Pereira, Alberto M.
AU - Veldhuis, Johannes D.
AU - Adriaanse, Ria
AU - Endert, Erik
AU - Fliers, Eric
AU - Romijn, Johannes A.
PY - 2009
Y1 - 2009
N2 - Context: The hypothalamo-pituitary-thyroid axis in women may differ from that in men. Previous reports have shown an almost 2-fold increased response to TRH in females compared with males. Objective: We analyzed TSH profiles in healthy men and women to delineate differences in the hypothalamo-pituitary-thyroid system. Subjects and Intervention: The subjects, 24 men (mean age 44 +/- 3 yr) and 22 women (mean age 42 +/- 3 yr) underwent a 24-h study with blood sampling intervals of 10 min. Premenopausal women were investigated in the early follicular phase of the cycle. Methods: Serum TSH concentration profiles were analyzed with a newly developed automated deconvolution program, approximate entropy, and cosinor regression. Results: Basal and pulsatile TSH secretion, and also pulse frequency, hormone half-lives, and secretory mode were indistinguishable in the two genders. There were no differences in diurnal variation, and the times of maximal secretion coincided. Approximate entropy, reflecting secretory regularity, was not different between men and women. In women but not men, TSH secretion was dependent linearly on age. Conclusions: TSH secretion is gender invariant and depends on age in women only. (J Clin Endocrinol Metab 94: 3964-3967, 2009)
AB - Context: The hypothalamo-pituitary-thyroid axis in women may differ from that in men. Previous reports have shown an almost 2-fold increased response to TRH in females compared with males. Objective: We analyzed TSH profiles in healthy men and women to delineate differences in the hypothalamo-pituitary-thyroid system. Subjects and Intervention: The subjects, 24 men (mean age 44 +/- 3 yr) and 22 women (mean age 42 +/- 3 yr) underwent a 24-h study with blood sampling intervals of 10 min. Premenopausal women were investigated in the early follicular phase of the cycle. Methods: Serum TSH concentration profiles were analyzed with a newly developed automated deconvolution program, approximate entropy, and cosinor regression. Results: Basal and pulsatile TSH secretion, and also pulse frequency, hormone half-lives, and secretory mode were indistinguishable in the two genders. There were no differences in diurnal variation, and the times of maximal secretion coincided. Approximate entropy, reflecting secretory regularity, was not different between men and women. In women but not men, TSH secretion was dependent linearly on age. Conclusions: TSH secretion is gender invariant and depends on age in women only. (J Clin Endocrinol Metab 94: 3964-3967, 2009)
U2 - https://doi.org/10.1210/jc.2009-1155
DO - https://doi.org/10.1210/jc.2009-1155
M3 - Article
C2 - 19773394
SN - 0021-972X
VL - 94
SP - 3964
EP - 3967
JO - Journal of clinical endocrinology and metabolism
JF - Journal of clinical endocrinology and metabolism
IS - 10
ER -