TY - JOUR
T1 - Time course of body composition changes in transgender adolescents during puberty suppression and sex hormone treatment
AU - Boogers, Lidewij Sophia
AU - Reijtenbagh, Sterre Johanna Petronella
AU - Wiepjes, Chantal Maria
AU - van Trotsenburg, Adrianus S. P.
AU - den Heijer, Martin
AU - Hannema, Sabine Elisabeth
N1 - © The Author(s) 2023. Published by Oxford University Press on behalf of the Endocrine Society.
PY - 2023/12/21
Y1 - 2023/12/21
N2 - CONTEXT: Transgender adolescents can undergo puberty suppression (PS) and subsequent gender-affirming hormone therapy (GAHT) but little information is available on the expected rate of physical changes.OBJECTIVE: To investigate the time course of body composition changes during PS and GAHT.DESIGN: Retrospective cohort study.SETTING: Gender identity clinic.PARTICIPANTS: 380 trans boys and 168 trans girls treated with PS prior to GAHT.MAIN OUTCOME MEASURES: Total lean- and fat mass Z-scores using birth-assigned sex as reference determined using dual energy X-ray absorptiometry.RESULTS: In trans boys, lean mass Z-scores decreased (-0.32, 95%CI -0.41; -0.23) and fat mass Z-scores increased (0.31, 95%CI 0.21; 0.41) in the first year of PS and remained stable thereafter. Only during the first year of testosterone, lean mass Z-scores increased (0.92, 95%CI 0.81; 1.04) and fat mass Z-scores decreased (-0.43, 95%CI -0.57; -0.29). In trans girls, both lean and fat mass Z-scores gradually changed over three years of PS (respectively -1.13, 95%CI -1.29; -0.98 and 1.06, 95%CI 0.90; 1.23). Only in the first year of GAHT, lean mass Z-scores decreased (-0.19, 95%CI -0.36; -0.03) while fat mass Z-scores remained unchanged after three years (-0.02, 95%CI -0.20; 0.16).CONCLUSIONS: Compared to peers, trans girls experienced ongoing lean mass decrease and fat mass increase during 3 years of PS while in trans boys smaller changes were observed that stabilized after one year. A large increase in lean mass Z-scores occurred only during the first year of testosterone treatment. In trans girls, body composition changed only slightly during GAHT. This information can improve counseling about treatment effects.
AB - CONTEXT: Transgender adolescents can undergo puberty suppression (PS) and subsequent gender-affirming hormone therapy (GAHT) but little information is available on the expected rate of physical changes.OBJECTIVE: To investigate the time course of body composition changes during PS and GAHT.DESIGN: Retrospective cohort study.SETTING: Gender identity clinic.PARTICIPANTS: 380 trans boys and 168 trans girls treated with PS prior to GAHT.MAIN OUTCOME MEASURES: Total lean- and fat mass Z-scores using birth-assigned sex as reference determined using dual energy X-ray absorptiometry.RESULTS: In trans boys, lean mass Z-scores decreased (-0.32, 95%CI -0.41; -0.23) and fat mass Z-scores increased (0.31, 95%CI 0.21; 0.41) in the first year of PS and remained stable thereafter. Only during the first year of testosterone, lean mass Z-scores increased (0.92, 95%CI 0.81; 1.04) and fat mass Z-scores decreased (-0.43, 95%CI -0.57; -0.29). In trans girls, both lean and fat mass Z-scores gradually changed over three years of PS (respectively -1.13, 95%CI -1.29; -0.98 and 1.06, 95%CI 0.90; 1.23). Only in the first year of GAHT, lean mass Z-scores decreased (-0.19, 95%CI -0.36; -0.03) while fat mass Z-scores remained unchanged after three years (-0.02, 95%CI -0.20; 0.16).CONCLUSIONS: Compared to peers, trans girls experienced ongoing lean mass decrease and fat mass increase during 3 years of PS while in trans boys smaller changes were observed that stabilized after one year. A large increase in lean mass Z-scores occurred only during the first year of testosterone treatment. In trans girls, body composition changed only slightly during GAHT. This information can improve counseling about treatment effects.
U2 - https://doi.org/10.1210/clinem/dgad750
DO - https://doi.org/10.1210/clinem/dgad750
M3 - Article
C2 - 38128064
SN - 0021-972X
JO - Journal of clinical endocrinology and metabolism
JF - Journal of clinical endocrinology and metabolism
ER -