Abstract
With functional MRI, we recently identified fronto-cerebellar activations in predicting time to reach a target and basal ganglia activation in velocity estimation, that is, small interval assessment. We now tested these functions in patients with Parkinson's disease (PD) and degenerative cerebellar ataxia. They watched a ball that repeatedly appeared, moved, and disappeared. Velocity, stop locations, and predicted target locations as well as time to reach a target were indicated. Compared with controls, PD patients showed impaired velocity estimation (momentary mode) whereas temporal prediction was selectively impaired in cerebellar ataxia patients. The latter highlights feed-forward processing within fronto-cerebellar circuitry. Impaired velocity estimation in PD fits the concept of a basal ganglia clock function.
Original language | English |
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Pages (from-to) | 1055-1059 |
Number of pages | 5 |
Journal | NeuroReport |
Volume | 19 |
Issue number | 10 |
DOIs | |
Publication status | Published - 2 Jul 2008 |
Keywords
- Anticipation
- Basal ganglia
- Cerebellar ataxia
- Cerebellum
- Parkinson's disease
- Timing